Blocking interactions between HIV-1 integrase and cellular cofactors: an emerging anti-retroviral strategy.

Abstract:

:HIV-1 integrase (IN) executes the insertion of proviral DNA into the host cell genome, an essential step in the retroviral life cycle. This is a multi-step process that starts in the cytosol and culminates in the nucleus of the infected cell. It is becoming increasingly clear that IN interacts with a wide range of different host-cell proteins throughout the viral life cycle. These cellular cofactors are exploited for various functions, including nuclear import, DNA target-site selection and virion assembly. The disruption of key interactions between IN and direct cellular cofactors affords a novel therapeutic approach for the design and development of new classes of anti-retroviral agents. Here, we will discuss the rationale behind this emerging and promising therapeutic strategy for HIV drug discovery. Our discussion includes the identified IN cellular cofactors, key research developments in the field and the implications this approach will have on the current HIV treatment regimen.

journal_name

Trends Pharmacol Sci

authors

Al-Mawsawi LQ,Neamati N

doi

10.1016/j.tips.2007.09.005

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

526-35

issue

10

eissn

0165-6147

issn

1873-3735

pii

S0165-6147(07)00209-X

journal_volume

28

pub_type

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