Abstract:
:The NLRP3 inflammasome is an intracellular multimeric protein complex which plays an important role in the pathogenesis of various human inflammatory diseases, such as diabetes, Alzheimer's disease and atherosclerosis. Recently, various G protein-coupled receptors (GPCRs) have been reported to be involved in the activation and regulation of the NLRP3 inflammasome by sensing multiple ions, metabolites, and neurotransmitters, suggesting GPCR signaling is an important regulator for NLRP3 inflammasome. Here, we will review how various GPCRs promote or inhibit NLRP3 inflammasome activation and discuss the implications of GPCRs as drug targets for the therapy of NLRP3-driven diseases.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Tang T,Gong T,Jiang W,Zhou Rdoi
10.1016/j.tips.2018.07.002subject
Has Abstractpub_date
2018-09-01 00:00:00pages
798-811issue
9eissn
0165-6147issn
1873-3735pii
S0165-6147(18)30107-Xjournal_volume
39pub_type
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