Abstract:
:There is increasing awareness of the compartmentalization of cAMP signalling--the means by which cAMP levels change in discrete domains of the cell with discrete local consequences. Current developments in understanding the organization of adenylyl cyclases in the plasma membrane are illuminating how the earliest part of cAMP compartmentalization could occur. This review focuses on recent findings regarding three levels of adenylyl cyclase organization--oligomerization, positioning to lipid rafts and participation in multiprotein signalling complexes. This organization, coupled with the role of scaffolding proteins in arranging the downstream effectors of cAMP, helps to identify complexes that greatly facilitate the translation of enzyme activation into local consequences.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Cooper DM,Crossthwaite AJdoi
10.1016/j.tips.2006.06.002subject
Has Abstractpub_date
2006-08-01 00:00:00pages
426-31issue
8eissn
0165-6147issn
1873-3735pii
S0165-6147(06)00150-7journal_volume
27pub_type
杂志文章,评审abstract::Traditional African medicine (TAM) is a shorthand reference to indigenous forms of healing that are practiced all over Africa. Although TAM is based on the accumulated experience of ancient Africans, its mode of transmission by word-of-mouth has hindered emergence of a generally accepted theory and hence of the system...
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