Rho kinase: a target for treating urinary bladder dysfunction?


:Urinary incontinence and other urinary storage symptoms are frequent in the general population but available treatments have limited efficacy and tolerability. Rho kinase (ROCK) has a central role in the regulation of smooth muscle contraction, including that of the urinary bladder. Recent experimental evidence indicates that this role could be deregulated and exacerbated in local and systemic pathological conditions that affect the bladder. In vitro studies with prototypical ROCK inhibitors such as Y27632 and in vivo data from animal models indicate that such drugs have potential as future treatments for bladder dysfunction.


Trends Pharmacol Sci


Peters SL,Schmidt M,Michel MC




Has Abstract


2006-09-01 00:00:00














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    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Pandey SC

    更新日期:2003-09-01 00:00:00

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    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Kapitulnik J,Maines MD

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    authors: Dev KK,Nakanishi S,Henley JM

    更新日期:2001-07-01 00:00:00

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    authors: Pujol A,Mosca R,Farrés J,Aloy P

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    authors: Gurevich VV,Gurevich EV

    更新日期:2008-05-01 00:00:00

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    abstract::Hypertension is prevalent and affects approximately 1 in every 4 adults in the Western world. Although many drugs are effective in treating hypertension, an individual's response to treatment is unpredictable. Pharmacogenetics holds the promise of becoming a tool to predict this response but obstacles and shortcomings...

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    pub_type: 杂志文章


    authors: Kurland L,Lind L,Melhus H

    更新日期:2005-09-01 00:00:00

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    authors: Tang T,Gong T,Jiang W,Zhou R

    更新日期:2018-09-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: McEwen BS

    更新日期:1991-04-01 00:00:00

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    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Boyda HN,Tse L,Procyshyn RM,Honer WG,Barr AM

    更新日期:2010-10-01 00:00:00

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    abstract::Since the cloning and expression of many of the G protein-coupled receptors during the 1980s, there has been a massive increase in our understanding of many aspects of their function. The use of molecular biology to engineer and express mutant receptors has made it possible to determine key amino acids involved in rec...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Haddad el-B,Rousell J

    更新日期:1998-08-01 00:00:00

  • Phosphodiesterases reduce spontaneous sinoatrial beating but not the 'fight or flight' tachycardia elicited by agonists through Gs-protein-coupled receptors.

    abstract::Cyclic AMP (cAMP) steers the generation of basal heart beat in the sinoatrial node. It also induces sinoatrial tachycardia and increased cardiac force, elicited through activation of Gs-protein-coupled receptors (GsPCRs). Phosphodiesterases (PDEs) hydrolyse cAMP. In the heart mainly PDE3 and PDE4 would be expected to ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章


    authors: Kaumann AJ

    更新日期:2011-07-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Weiss JH,Sensi SL,Koh JY

    更新日期:2000-10-01 00:00:00

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    abstract::Disorders of the central nervous system (CNS) have many etiologies compounded by limited options for treatment. The lack of successful treatments for these disorders stems from the difficulty of gaining effective access to the CNS through the blood-brain barrier, and the irreplaceable nature of neurons. Here, we revie...

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    authors: Valente LA,Begg LR,Filiano AJ

    更新日期:2019-07-01 00:00:00

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    abstract::The fruit fly Drosophila melanogaster has been used for modeling cancer and as an in vivo tool for the validation and/or development of cancer therapeutics. The impetus for the use of Drosophila in cancer research stems from the high conservation of its signaling pathways, lower genetic redundancy, short life cycle, g...

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    pub_type: 杂志文章,评审


    authors: Yadav AK,Srikrishna S,Gupta SC

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    abstract::The importance of the inhibitory neurotransmitter, GABA, within higher centres of the mammalian brain is unquestionable. However, its role within the spinal cord is of equal significance. There have been numerous studies over the past two decades that have established GABA as a neurotransmitter at both post- and presy...

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    pub_type: 杂志文章,评审


    authors: Malcangio M,Bowery NG

    更新日期:1996-12-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: McCarthy SA,Kuzu I,Gatter KC,Bicknell R

    更新日期:1991-12-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Lechleiter J,Peralta E,Clapham D

    更新日期:1989-12-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Drouin-Ouellet J,Cicchetti F

    更新日期:2012-10-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Clarke WP,Bond RA

    更新日期:1998-07-01 00:00:00

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    abstract::Recent studies have proposed a functional link between annexin 1 (ANXA1), an endogenous anti-inflammatory mediator, and receptors of the formyl-peptide family. In particular, exogenous and endogenous ANXA1 and its peptidomimetics interact with one member of this family, the formyl-peptide-receptor-like 1. Further anal...

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    authors: Perretti M

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    authors: Bock A,Kostenis E,Tränkle C,Lohse MJ,Mohr K

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    authors: Rodionov RN,Jarzebska N,Weiss N,Lentz SR

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    authors: Ward WH,Timms D,Fersht AR

    更新日期:1990-07-01 00:00:00

  • Cancer and Microenvironment Plasticity: Double-Edged Swords in Metastasis.

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    journal_title:Trends in pharmacological sciences

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    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Spedding M,Kenny B,Chatelain P

    更新日期:1995-04-01 00:00:00

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    journal_title:Trends in pharmacological sciences

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    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Milligan G

    更新日期:1993-11-01 00:00:00

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    authors: Wisskirchen K,Lucifora J,Michler T,Protzer U

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