Rho kinase: a target for treating urinary bladder dysfunction?

Abstract:

:Urinary incontinence and other urinary storage symptoms are frequent in the general population but available treatments have limited efficacy and tolerability. Rho kinase (ROCK) has a central role in the regulation of smooth muscle contraction, including that of the urinary bladder. Recent experimental evidence indicates that this role could be deregulated and exacerbated in local and systemic pathological conditions that affect the bladder. In vitro studies with prototypical ROCK inhibitors such as Y27632 and in vivo data from animal models indicate that such drugs have potential as future treatments for bladder dysfunction.

journal_name

Trends Pharmacol Sci

authors

Peters SL,Schmidt M,Michel MC

doi

10.1016/j.tips.2006.07.002

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

492-7

issue

9

eissn

0165-6147

issn

1873-3735

pii

S0165-6147(06)00174-X

journal_volume

27

pub_type

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