Discoidin Domains as Emerging Therapeutic Targets.

Abstract:

:Discoidin (DS) domains are found in eukaryotic and prokaryotic extracellular and transmembrane multidomain proteins. These small domains play different functional roles and can interact with phospholipids, glycans, and proteins, including collagens. DS domain-containing proteins are often involved in cellular adhesion, migration, proliferation, and matrix-remodeling events, while some play a major role in blood coagulation. Mutations in DS domains have been associated with various disease conditions. This review provides an update on the structure, function, and modulation of the DS domains, with a special emphasis on two circulating blood coagulation cofactors, factor V and factor VIII, and the transmembrane neuropilin receptors that have been targeted for inhibition by biologics and small chemical compounds.

journal_name

Trends Pharmacol Sci

authors

Villoutreix BO,Miteva MA

doi

10.1016/j.tips.2016.06.003

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

641-659

issue

8

eissn

0165-6147

issn

1873-3735

pii

S0165-6147(16)30070-0

journal_volume

37

pub_type

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