Abstract:
:Discoidin (DS) domains are found in eukaryotic and prokaryotic extracellular and transmembrane multidomain proteins. These small domains play different functional roles and can interact with phospholipids, glycans, and proteins, including collagens. DS domain-containing proteins are often involved in cellular adhesion, migration, proliferation, and matrix-remodeling events, while some play a major role in blood coagulation. Mutations in DS domains have been associated with various disease conditions. This review provides an update on the structure, function, and modulation of the DS domains, with a special emphasis on two circulating blood coagulation cofactors, factor V and factor VIII, and the transmembrane neuropilin receptors that have been targeted for inhibition by biologics and small chemical compounds.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Villoutreix BO,Miteva MAdoi
10.1016/j.tips.2016.06.003subject
Has Abstractpub_date
2016-08-01 00:00:00pages
641-659issue
8eissn
0165-6147issn
1873-3735pii
S0165-6147(16)30070-0journal_volume
37pub_type
杂志文章,评审abstract::Until recently, release studies have failed to indicate the existence of autoreceptors on motor nerves. Ignaz Wessler now reports on a refinement of the technique - the measurement of newly synthesized [3H]acetylcholine released from the phrenic nerve - which provides clear evidence in support of release-modulating au...
journal_title:Trends in pharmacological sciences
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doi:10.1016/0165-6147(89)90208-3
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abstract::Release of cytotoxic granule proteins from activated eosinophil granules is considered to be a key pathogenic mechanism in eosinophilic diseases. Degenerated eosinophils and extracellular eosinophil granules have been repeatedly depicted. The present overview describes evidence that eosinophil lysis and distribution o...
journal_title:Trends in pharmacological sciences
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abstract::The injectisome type three secretion system (T3SS) is a major virulence factor in Pseudomonas aeruginosa. This bacterium is responsible for severe infections in immunosuppressed or cystic fibrosis patients and has become resistant to many antibiotics. Inhibitors of T3SS may therefore constitute an innovative therapeut...
journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tips.2016.05.011
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abstract::Signal transducer and activator of transcription 3 (STAT3) plays crucial roles in several cellular processes such as cell proliferation and survival, and has been found to be aberrantly activated in many cancers. Much research has explored the leading mechanisms for regulating the STAT3 pathway and its role in promoti...
journal_title:Trends in pharmacological sciences
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journal_title:Trends in pharmacological sciences
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journal_title:Trends in pharmacological sciences
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doi:10.1016/j.tips.2013.01.009
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abstract::The metabotropic glutamate (mGlu) receptors are a family of G-protein-coupled receptors (GPCRs) that regulate cell physiology throughout the nervous system. The potential of mGlu receptors as therapeutic targets has been bolstered by current research that has provided insight into the diverse modes of mGlu activation ...
journal_title:Trends in pharmacological sciences
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
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更新日期:2015-05-01 00:00:00
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journal_title:Trends in pharmacological sciences
pub_type: 历史文章,杂志文章
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
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更新日期:1997-10-01 00:00:00
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tips.2006.05.007
更新日期:2006-07-01 00:00:00
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
doi:10.1016/0165-6147(93)90071-q
更新日期:1993-03-01 00:00:00
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tips.2014.01.004
更新日期:2014-03-01 00:00:00
abstract::G protein-coupled receptors (GPCRs) comprise a large and diverse class of signal-transducing receptors that undergo dynamic and isoform-specific membrane trafficking. GPCRs thus have an inherent potential to initiate or regulate signaling reactions from multiple membrane locations. This review discusses emerging insig...
journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tips.2017.11.009
更新日期:2018-02-01 00:00:00
abstract::NMDA and non-NMDA (AMPA/kainate) antagonists have potential in the treatment of a diverse group of neurological disorders associated with excessive activation of excitatory amino acid receptors. Here Michael Rogawski reviews recent progress in the development of therapeutically useful NMDA receptor channel blockers an...
journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
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journal_title:Trends in pharmacological sciences
pub_type: 评论,杂志文章
doi:10.1016/j.tips.2020.05.001
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abstract::Tissue factor (TF) is the cellular receptor and cofactor for blood coagulation factor VII (FVII). Exposure of flowing blood to cells that express TF leads to the initiation of blood coagulation. A recent study of mice expressing low levels of TF has demonstrated the importance of TF and FVII in maintaining adequate ha...
journal_title:Trends in pharmacological sciences
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
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journal_title:Trends in pharmacological sciences
pub_type: 评论,信件
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journal_title:Trends in pharmacological sciences
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
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journal_title:Trends in pharmacological sciences
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journal_title:Trends in pharmacological sciences
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abstract::Oxidative stress is a key pathologic factor in neurodegenerative diseases such as Alzheimer and Parkinson diseases (AD, PD). The failure of free-radical-scavenging antioxidants in clinical trials pinpoints an urgent need to identify and to block major sources of oxidative stress in neurodegenerative diseases. As a maj...
journal_title:Trends in pharmacological sciences
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journal_title:Trends in pharmacological sciences
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journal_title:Trends in pharmacological sciences
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abstract::Pairing orphan G-protein-coupled receptors (GPCRs) to potential ligands found in tissue extracts or in libraries of synthetic compounds has identified an ever-increasing number of transmitters, some of which are novel, some of which were previously known and, more recently, some of which are unexpected. These discover...
journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
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更新日期:2005-01-01 00:00:00
abstract::B7x (B7 homolog x, also known as B7-H4, B7S1, and VTCN1) was discovered by ourselves and others in 2003 as the seventh member of the B7 family. It is an inhibitory immune checkpoint of great significance to human disease. Tissue-expressed B7x minimizes autoimmune and inflammatory responses. It is overexpressed in a br...
journal_title:Trends in pharmacological sciences
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doi:10.1016/j.tips.2019.09.008
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