Eosinophil lysis and free granules: an in vivo paradigm for cell activation and drug development.

Abstract:

:Release of cytotoxic granule proteins from activated eosinophil granules is considered to be a key pathogenic mechanism in eosinophilic diseases. Degenerated eosinophils and extracellular eosinophil granules have been repeatedly depicted. The present overview describes evidence that eosinophil lysis and distribution of free eosinophil granules (as opposed to 'classical degranulation') is an important mechanism by which eosinophils affect their surroundings. Here, Carl Persson and Jonas Erjefält summarize how recent reports on the induction of eosinophil lysis in vivo provide a new paradigm for eosinophil activation and thus constitute a novel basis for pharmacological manipulations in eosinophilic diseases.

journal_name

Trends Pharmacol Sci

authors

Persson CG,Erjefält JS

doi

10.1016/s0165-6147(97)01042-0

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

117-23

issue

4

eissn

0165-6147

issn

1873-3735

pii

S0165-6147(97)01042-0

journal_volume

18

pub_type

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