Abstract:
:The hypothalamic neuropeptide oxytocin (OT) has attracted the attention both of the scientific community and a general audience because of its prosocial effects in mammals, and OT is now seen as a facilitator of mammalian species propagation. Furthermore, OT is a candidate for the treatment of social deficits in several neuropsychiatric and neurodevelopmental conditions. Despite such possibilities and a long history of studies on OT behavioral effects, the mechanisms of OT actions in the brain remain poorly understood. In the present review, based on anatomical, biochemical, electrophysiological, and behavioral studies, we propose a novel model of local OT actions in the central nervous system (CNS) via focused axonal release, which initiates intracellular signaling cascades in specific OT-sensitive neuronal populations and coordinated brain region-specific behaviors.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Chini B,Verhage M,Grinevich Vdoi
10.1016/j.tips.2017.08.005subject
Has Abstractpub_date
2017-11-01 00:00:00pages
982-991issue
11eissn
0165-6147issn
1873-3735pii
S0165-6147(17)30165-7journal_volume
38pub_type
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