Abstract：
:The melanocortin receptors are a subfamily of G-protein-coupled, rhodopsin-like receptors that are rapidly being acknowledged as an extremely promising target for pharmacological intervention in a variety of different inflammatory pathologies, including stroke. Stroke continues to be a leading cause of death worldwide, with risk factors including smoking, diabetes, hypertension and obesity. The pathophysiology of stroke is highly complex: reintroduction of blood flow to the infarcted brain region is paramount in limiting ischaemic damage caused by stroke, yet a concomitant inflammatory response can compound tissue damage. The possibilities of pro-resolving treatments that target this inflammatory response have only recently begun to be explored. This review discusses the endogenous roles of the melanocortin system in reducing characterized aspects of inflammation, and how these, together with potent neuroprotective actions, suggest its potential as a therapeutic target in stroke.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Holloway PM,Smith HK,Renshaw D,Flower RJ,Getting SJ,Gavins FNdoi
10.1016/j.tips.2010.11.010subject
Has Abstractpub_date
2011-02-01 00:00:00pages
90-8issue
2eissn
0165-6147issn
1873-3735pii
S0165-6147(10)00211-7journal_volume
32pub_type
杂志文章,评审abstract：:Advances in the understanding of the sense of smell have increased awareness of the role of olfaction in human life. Odors are perceived via specific G protein-coupled receptors (GPCRs) with cAMP as the second messenger. Drugs that interact with this signaling cascade, such as opioids, cannabinoids and sildenafil, are...
journal_title：Trends in pharmacological sciences
pub_type： 杂志文章,评审
doi：10.1016/j.tips.2012.01.004
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journal_title：Trends in pharmacological sciences
pub_type： 杂志文章,评审
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journal_title：Trends in pharmacological sciences
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journal_title：Trends in pharmacological sciences
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journal_title：Trends in pharmacological sciences
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journal_title：Trends in pharmacological sciences
pub_type： 杂志文章,评审
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journal_title：Trends in pharmacological sciences
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journal_title：Trends in pharmacological sciences
pub_type： 评论,杂志文章
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pub_type： 杂志文章,评审
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journal_title：Trends in pharmacological sciences
pub_type： 杂志文章,评审
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journal_title：Trends in pharmacological sciences
pub_type： 杂志文章,评审
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更新日期：2004-06-01 00:00:00
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journal_title：Trends in pharmacological sciences
pub_type： 杂志文章,评审
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更新日期：2006-05-01 00:00:00
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journal_title：Trends in pharmacological sciences
pub_type： 杂志文章,评审
doi：10.1016/j.tips.2009.10.006
更新日期：2010-01-01 00:00:00
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journal_title：Trends in pharmacological sciences
pub_type： 杂志文章,评审
doi：10.1016/j.tips.2012.07.002
更新日期：2012-10-01 00:00:00
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journal_title：Trends in pharmacological sciences
pub_type： 杂志文章,评审
doi：10.1016/j.tips.2008.07.009
更新日期：2008-10-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Trends in pharmacological sciences
pub_type： 新闻
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更新日期：2002-05-01 00:00:00
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journal_title：Trends in pharmacological sciences
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doi：10.1016/j.tips.2006.09.002
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journal_title：Trends in pharmacological sciences
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journal_title：Trends in pharmacological sciences
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journal_title：Trends in pharmacological sciences
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journal_title：Trends in pharmacological sciences
pub_type： 杂志文章,评审
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更新日期：2003-11-01 00:00:00
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journal_title：Trends in pharmacological sciences
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journal_title：Trends in pharmacological sciences
pub_type： 杂志文章,评审
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更新日期：2006-08-01 00:00:00
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journal_title：Trends in pharmacological sciences
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journal_title：Trends in pharmacological sciences
pub_type： 杂志文章,评审
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abstract：:During the past decade, translocator protein 18 kDa (TSPO), previously named peripheral benzodiazepine receptor, has gained a great deal of attention based on its use as a clinical biomarker of neuroinflammation with therapeutic potential. However, there is a paucity of knowledge on the function(s) of TSPO in glial ce...
journal_title：Trends in pharmacological sciences
pub_type： 杂志文章,评审
doi：10.1016/j.tips.2016.02.008
更新日期：2016-05-01 00:00:00
