The annexin 1 receptor(s): is the plot unravelling?

Abstract:

:Recent studies have proposed a functional link between annexin 1 (ANXA1), an endogenous anti-inflammatory mediator, and receptors of the formyl-peptide family. In particular, exogenous and endogenous ANXA1 and its peptidomimetics interact with one member of this family, the formyl-peptide-receptor-like 1. Further analyses of the interactions between ANXA1 and this and other members of this receptor family, and a better characterization of the ANXA1 receptor systems in models of inflammation, might clarify their mechanism of anti-inflammatory effects. This line of research will facilitate the development of ANXA1 mimetics and take advantage of >20 years of biological research into the functions of this glucocorticoid-modulated protein.

journal_name

Trends Pharmacol Sci

authors

Perretti M

doi

10.1016/j.tips.2003.09.010

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

574-9

issue

11

eissn

0165-6147

issn

1873-3735

pii

S0165-6147(03)00302-X

journal_volume

24

pub_type

杂志文章,评审
  • How and why do GPCRs dimerize?

    abstract::Dimerization is fairly common in the G-protein-coupled receptor (GPCR) superfamily. First attempts to rationalize this phenomenon gave rise to an idea that two receptors in a dimer could be necessary to bind a single molecule of G protein or arrestin. Although GPCRs, G proteins and arrestins were crystallized only in ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/j.tips.2008.02.004

    authors: Gurevich VV,Gurevich EV

    更新日期:2008-05-01 00:00:00

  • Quantitative approaches to analyzing imatinib-treated chronic myeloid leukemia.

    abstract::Progress in understanding the genetic changes that drive tumorigenesis has enabled the development of molecularly targeted anticancer therapy. The first small molecule targeted to a specific protein was imatinib mesylate (Gleevec, STI571), which is used to treat chronic myeloid leukemia (CML). A recent article present...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/j.tips.2007.03.003

    authors: Michor F

    更新日期:2007-05-01 00:00:00

  • Novel anxiolytics that act as partial agonists at benzodiazepine receptors.

    abstract::Benzodiazepines in clinical use have a range of pharmacological activities. Some, e.g. sedation, tolerance and addiction, are not welcome. Undesirable side-effects of drugs are often controlled by developing compounds that bind more selectively to one particular receptor subtype. An alternative approach, discussed her...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/0165-6147(90)90126-s

    authors: Haefely W,Martin JR,Schoch P

    更新日期:1990-11-01 00:00:00

  • Human Brain Neuropharmacology: A Platform for Translational Neuroscience.

    abstract::Central nervous system (CNS) drug development has been plagued by a failure to translate effective therapies from the lab to the clinic. There are many potential reasons for this, including poor understanding of brain pharmacokinetic (PK) and pharmacodynamic (PD) factors, preclinical study flaws, clinical trial design...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2020.09.002

    authors: Dragunow M

    更新日期:2020-11-01 00:00:00

  • Molecular characterization of alpha 1- and alpha 2-adrenoceptors.

    abstract::Three 'alpha 1-adrenoceptors' and three 'alpha 2-adrenoceptors' have now been cloned. How closely do these receptors match the native receptors that have been identified pharmacologically? What are the properties of these receptors, and how do they relate to other members of the cationic amine receptor family? Kevin L...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/0165-6147(91)90499-i

    authors: Harrison JK,Pearson WR,Lynch KR

    更新日期:1991-02-01 00:00:00

  • Acquired somatic mutations in the molecular pathogenesis of COPD.

    abstract::Chronic obstructive pulmonary disease (COPD) is caused mostly by cigarette smoking but its specific molecular mechanisms are obscure. Current theories suggest that the inflammation and oxidative stress induced by smoking lead to proteolytic imbalance and progressive lung structural derangement, with disease susceptibi...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/S0165-6147(02)00052-4

    authors: Anderson GP,Bozinovski S

    更新日期:2003-02-01 00:00:00

  • Agonist regulation of cellular G protein levels and distribution: mechanisms and functional implications.

    abstract::Exposure of cells to agonists of receptors linked to G proteins can result in downregulation of cellular levels or redistribution of G proteins from membranes to the cytosol. Agonist-induced reductions in G protein levels have been observed for members of each of the Gs, Gi and Gq families of G proteins, are likely to...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/0165-6147(93)90064-Q

    authors: Milligan G

    更新日期:1993-11-01 00:00:00

  • Preclinical models of antipsychotic drug-induced metabolic side effects.

    abstract::Antipsychotic drugs (APDs), and the 'atypical' APDs in particular, are commonly associated with metabolic side effects in humans. These include glucose dysregulation, insulin resistance, hyperlipidemia, weight gain and hypertension, which put patients at increased risk of cardiometabolic disorders. The underlying biol...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2010.07.002

    authors: Boyda HN,Tse L,Procyshyn RM,Honer WG,Barr AM

    更新日期:2010-10-01 00:00:00

  • Targeting the melanocortin receptor system for anti-stroke therapy.

    abstract::The melanocortin receptors are a subfamily of G-protein-coupled, rhodopsin-like receptors that are rapidly being acknowledged as an extremely promising target for pharmacological intervention in a variety of different inflammatory pathologies, including stroke. Stroke continues to be a leading cause of death worldwide...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2010.11.010

    authors: Holloway PM,Smith HK,Renshaw D,Flower RJ,Getting SJ,Gavins FN

    更新日期:2011-02-01 00:00:00

  • Identifying Missing Biosynthesis Enzymes of Plant Natural Products.

    abstract::Elucidating plant-specialized biosynthetic pathways has always constituted a laborious task, notably for natural products with high pharmaceutical values. Here, we discuss emerging omics-based strategies that facilitate the identification of genes from these complex metabolic pathways, paving the way to engineered sup...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/j.tips.2019.12.006

    authors: Dugé de Bernonville T,Papon N,Clastre M,O'Connor SE,Courdavault V

    更新日期:2020-03-01 00:00:00

  • Ca2+ channel beta-subunits: structural insights AID our understanding.

    abstract::It has taken 17 years from the first identification of a voltage-gated Ca2+ channel (CaV) beta-subunit as a band on a gel following purification of skeletal muscle dihydropyridine (DHP) receptors in 1987 to the publication of key information on the structures of Ca2+ channel beta-subunits. Three recent X-ray crystallo...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2004.10.008

    authors: Richards MW,Butcher AJ,Dolphin AC

    更新日期:2004-12-01 00:00:00

  • Novel Therapeutic Targets for Managing Dyslipidemia.

    abstract::Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of morbidity and mortality in developed nations. Therapeutic modulation of dyslipidemia by inhibiting 3'-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase is standard practice throughout the world. However, based on findings from Mendelian ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2018.06.001

    authors: Sathiyakumar V,Kapoor K,Jones SR,Banach M,Martin SS,Toth PP

    更新日期:2018-08-01 00:00:00

  • New drug binding sites in Ca2+ channels.

    abstract::New classes of drugs modifying Ca2+ channel activity have become available, this may enlarge the clinical utilities that have been associated with established Ca2+ channel antagonists such as the dihydropyridines (for example, nifedipine). Two such classes are reviewed by Michael Spedding, Barry Kenny and Pierre Chate...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-6147(00)89002-1

    authors: Spedding M,Kenny B,Chatelain P

    更新日期:1995-04-01 00:00:00

  • Receptors coupled to heterotrimeric G proteins of the G12 family.

    abstract::Much regarding the engagement of the G(12) family of heterotrimeric G proteins (G(12) and G(13)) by agonist-activated receptors remains unclear. For example, the identity of receptors that couple unequivocally to G(12) and G(13) and how signals are allocated among these and other G proteins remain open questions. Part...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2005.01.007

    authors: Riobo NA,Manning DR

    更新日期:2005-03-01 00:00:00

  • Receptor-activated Ca2+ influx: how many mechanisms for how many channels?

    abstract::Receptors that are coupled to the production of inositol (1,4,5)-trisphosphate cause an increase in cytosolic free Ca2+ concentration as a consequence of both Ca2+ mobilization from intracellular stores and Ca2+ influx through the plasma membrane. Although this latter phenomenon appears attributable to the activation ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/0165-6147(94)90282-8

    authors: Fasolato C,Innocenti B,Pozzan T

    更新日期:1994-03-01 00:00:00

  • New advances in NMDA receptor pharmacology.

    abstract::N-Methyl-D-aspartate (NMDA) receptors are tetrameric ion channels containing two of four possible GluN2 subunits. These receptors have been implicated for decades in neurological diseases such as stroke, traumatic brain injury, dementia and schizophrenia. The GluN2 subunits substantially contribute to functional diver...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2011.08.003

    authors: Ogden KK,Traynelis SF

    更新日期:2011-12-01 00:00:00

  • New insights into activation of the steroid hormone receptor superfamily.

    abstract::For many years the prevailing view of how steroid hormone receptors exert their effects on gene transcription has been that these intracellular receptor proteins, upon association with their specific cognate ligands, undergo a transformation to a state where they are capable of interacting with chromatin and regulatin...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/0165-6147(92)90099-r

    authors: Power RF,Conneely OM,O'Malley BW

    更新日期:1992-08-01 00:00:00

  • GABA and its receptors in the spinal cord.

    abstract::The importance of the inhibitory neurotransmitter, GABA, within higher centres of the mammalian brain is unquestionable. However, its role within the spinal cord is of equal significance. There have been numerous studies over the past two decades that have established GABA as a neurotransmitter at both post- and presy...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-6147(96)01013-9

    authors: Malcangio M,Bowery NG

    更新日期:1996-12-01 00:00:00

  • Nematode genome sequence dramatically extends the nuclear receptor superfamily.

    abstract::Nuclear receptors represent a large class of ligand-activated transcriptional regulators; about 70 members of this protein family have been cloned from mammalian or insect species. Thus, it came as a great surprise when the recent completion of the Caenorhabditis elegans genome revealed at least 228 genes for nuclear ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-6147(99)01417-0

    authors: Enmark E,Gustafsson JA

    更新日期:2000-03-01 00:00:00

  • Eosinophil lysis and free granules: an in vivo paradigm for cell activation and drug development.

    abstract::Release of cytotoxic granule proteins from activated eosinophil granules is considered to be a key pathogenic mechanism in eosinophilic diseases. Degenerated eosinophils and extracellular eosinophil granules have been repeatedly depicted. The present overview describes evidence that eosinophil lysis and distribution o...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-6147(97)01042-0

    authors: Persson CG,Erjefält JS

    更新日期:1997-04-01 00:00:00

  • The sigma-1 receptor chaperone as an inter-organelle signaling modulator.

    abstract::Inter-organelle signaling plays important roles in many physiological functions. Endoplasmic reticulum (ER)-mitochondrion signaling affects intramitochondrial calcium (Ca(2+)) homeostasis and cellular bioenergetics. ER-nucleus signaling attenuates ER stress. ER-plasma membrane signaling regulates cytosolic Ca(2+) home...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/j.tips.2010.08.007

    authors: Su TP,Hayashi T,Maurice T,Buch S,Ruoho AE

    更新日期:2010-12-01 00:00:00

  • Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin.

    abstract::Degradation of heme requires its conversion to biliverdin (BV) by heme oxygenase, followed by reduction of BV to the free-radical quencher bilirubin (BR) by biliverdin reductase (BVR). It is now recognized that human BVR (hBVR) is a dual-specificity kinase (Ser/Thr and Tyr) upstream activator of the insulin/insulin gr...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2008.12.003

    authors: Kapitulnik J,Maines MD

    更新日期:2009-03-01 00:00:00

  • Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines.

    abstract::NMDA and non-NMDA (AMPA/kainate) antagonists have potential in the treatment of a diverse group of neurological disorders associated with excessive activation of excitatory amino acid receptors. Here Michael Rogawski reviews recent progress in the development of therapeutically useful NMDA receptor channel blockers an...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/0165-6147(93)90005-5

    authors: Rogawski MA

    更新日期:1993-09-01 00:00:00

  • Pharmacological Research as a Key Component in Mitigating the Opioid Overdose Crisis.

    abstract::The United States is experiencing an epidemic of opioid overdose deaths. Many of the recent fatalities are associated with illicitly manufactured fentanyl, which is being added to heroin and counterfeit pain pills. The crisis is further exacerbated by the emergence of an increasing number of novel synthetic opioids (N...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2018.09.006

    authors: Baumann MH,Kopajtic TA,Madras BK

    更新日期:2018-12-01 00:00:00

  • Modulation of transmitter release via presynaptic cannabinoid receptors.

    abstract::Cannabis (marijuana) is not only a frequently abused drug but also has the potential for the development of useful agents for the treatment of emesis, anorexia and multiple sclerosis. In this article, the effects of modulation of transmitter release by cannabinoids in both the CNS and the PNS of various species, inclu...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-6147(00)01805-8

    authors: Schlicker E,Kathmann M

    更新日期:2001-11-01 00:00:00

  • Stimulants and the developing brain.

    abstract::For almost 70 years, children have received stimulants for the treatment of attention deficit hyperactivity disorder [ADHD (initially called hyperkinetic syndrome)], with little understanding of the long-term effects of these drugs on brain development. The maturation and refinement of the brain during childhood and a...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2005.03.009

    authors: Andersen SL

    更新日期:2005-05-01 00:00:00

  • Excitatory actions of adenosine on ventricular automaticity.

    abstract::Due to its negative chronotropic and inotropic effects, adenosine has to date been considered as a cardiodepressant agent. However, adenosine increases ventricular automaticity. This review by Jesus Hernández and Alexandre Ribeiro discusses the experimental and clinical evidence for the excitatory effects of adenosine...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/0165-6147(96)81589-6

    authors: Hernández J,Ribeiro JA

    更新日期:1996-04-01 00:00:00

  • Insight into the Structural Features of TSPO: Implications for Drug Development.

    abstract::The translocator protein (TSPO), an 18-kDa transmembrane protein primarily found in the outer mitochondrial membrane, is evolutionarily conserved and widely distributed across species. In mammals, TSPO has been described as a key member of a multiprotein complex involved in many putative functions and, over the years,...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2019.11.005

    authors: Lacapere JJ,Duma L,Finet S,Kassiou M,Papadopoulos V

    更新日期:2020-02-01 00:00:00

  • The minor binding pocket: a major player in 7TM receptor activation.

    abstract::From the deep part of the main ligand-binding crevice, a minor, often shallower pocket extends between the extracellular ends of transmembrane domains (TM)-I, II, III and VII of 7TM receptors. This minor binding pocket is defined by a highly conserved kink in TM-II that is induced by a proline residue located in one o...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/j.tips.2010.08.006

    authors: Rosenkilde MM,Benned-Jensen T,Frimurer TM,Schwartz TW

    更新日期:2010-12-01 00:00:00

  • Biological Evidence for Paradoxical Improvement of Psychiatric Disorder Symptoms by Addictive Drugs.

    abstract::Addiction biology has focused on the mechanisms of the positive and negative reinforcing actions of addictive drugs but neglected potential benefits. Two new studies provide the first insights into a neurobiology of psychoactive drug instrumentalization. This may help us design better models for addiction neuroscience...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/j.tips.2017.03.005

    authors: Müller CP,Kornhuber J

    更新日期:2017-06-01 00:00:00