Regulation of transcription factor activity by interconnected post-translational modifications.

Abstract:

:Transcription factors comprise just over 7% of the human proteome and serve as gatekeepers of cellular function, integrating external signal information into gene expression programs that reconfigure cellular physiology at the most basic levels. Surface-initiated cell signaling pathways converge on transcription factors, decorating these proteins with an array of post-translational modifications (PTMs) that are often interdependent, being linked in time, space, and combinatorial function. These PTMs orchestrate every activity of a transcription factor over its entire lifespan--from subcellular localization to protein-protein interactions, sequence-specific DNA binding, transcriptional regulatory activity, and protein stability--and play key roles in the epigenetic regulation of gene expression. The multitude of PTMs of transcription factors also offers numerous potential points of intervention for development of therapeutic agents to treat a wide spectrum of diseases. We review PTMs most commonly targeting transcription factors, focusing on recent reports of sequential and linked PTMs of individual factors.

journal_name

Trends Pharmacol Sci

authors

Filtz TM,Vogel WK,Leid M

doi

10.1016/j.tips.2013.11.005

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

76-85

issue

2

eissn

0165-6147

issn

1873-3735

pii

S0165-6147(13)00225-3

journal_volume

35

pub_type

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