Abstract:
:Transcription factors comprise just over 7% of the human proteome and serve as gatekeepers of cellular function, integrating external signal information into gene expression programs that reconfigure cellular physiology at the most basic levels. Surface-initiated cell signaling pathways converge on transcription factors, decorating these proteins with an array of post-translational modifications (PTMs) that are often interdependent, being linked in time, space, and combinatorial function. These PTMs orchestrate every activity of a transcription factor over its entire lifespan--from subcellular localization to protein-protein interactions, sequence-specific DNA binding, transcriptional regulatory activity, and protein stability--and play key roles in the epigenetic regulation of gene expression. The multitude of PTMs of transcription factors also offers numerous potential points of intervention for development of therapeutic agents to treat a wide spectrum of diseases. We review PTMs most commonly targeting transcription factors, focusing on recent reports of sequential and linked PTMs of individual factors.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Filtz TM,Vogel WK,Leid Mdoi
10.1016/j.tips.2013.11.005subject
Has Abstractpub_date
2014-02-01 00:00:00pages
76-85issue
2eissn
0165-6147issn
1873-3735pii
S0165-6147(13)00225-3journal_volume
35pub_type
杂志文章,评审abstract::The purpose of this Opinion is to present a case for targeting sphingosine kinase 2 (SK2) in autoimmune/inflammatory disease. Data obtained using Sphk2-/- mice suggest that SK2 is an anti-inflammatory enzyme, although this might be misleading because of a compensatory increase in the expression of a second isoform, sp...
journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tips.2017.04.003
更新日期:2017-07-01 00:00:00
abstract::The enzyme methylenetetrahydrofolate reductase (MTHFR) directs folate species either to DNA synthesis or to homocysteine (Hcy) remethylation. The common MTHFR C677T polymorphism affects the activity of the enzyme and hence folate distribution. Under conditions of impaired folate status, the homozygous TT genotype has ...
journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
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abstract::As we have learnt from earlier articles in our series on the pharmacology of excitatory amino acids, neurons and glia express several subtypes of excitatory amino acid receptor, the activation of which increases intracellular free calcium ion concentration. In this sixth article, Mark Mayer and Richard Miller detail t...
journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
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journal_title:Trends in pharmacological sciences
pub_type: 传,历史文章,杂志文章
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更新日期:1989-07-01 00:00:00
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tips.2006.10.007
更新日期:2006-12-01 00:00:00
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tips.2008.12.003
更新日期:2009-03-01 00:00:00
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tips.2015.07.007
更新日期:2015-11-01 00:00:00
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
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更新日期:2015-08-01 00:00:00
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tips.2016.08.001
更新日期:2016-11-01 00:00:00
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tips.2009.02.005
更新日期:2009-05-01 00:00:00
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tips.2005.11.007
更新日期:2006-01-01 00:00:00
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tips.2010.11.010
更新日期:2011-02-01 00:00:00
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tips.2014.11.003
更新日期:2015-02-01 00:00:00
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tips.2016.05.010
更新日期:2016-09-01 00:00:00
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tips.2017.10.007
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
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journal_title:Trends in pharmacological sciences
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journal_title:Trends in pharmacological sciences
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tips.2007.09.005
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tips.2009.10.006
更新日期:2010-01-01 00:00:00
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tips.2013.02.001
更新日期:2013-04-01 00:00:00
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journal_title:Trends in pharmacological sciences
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更新日期:2011-11-01 00:00:00
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tips.2019.09.008
更新日期:2019-11-01 00:00:00
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journal_title:Trends in pharmacological sciences
pub_type: 杂志文章,评审
doi:10.1016/s0165-6147(00)01865-4
更新日期:2002-01-01 00:00:00
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journal_title:Trends in pharmacological sciences
pub_type: 新闻
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更新日期:2002-10-01 00:00:00