Abstract：
:The sialic-acid-binding immunoglobulin-like lectins (siglecs) comprise a family of receptors that are differentially expressed on leukocytes and other immune cells. The restricted expression of several siglecs to one or a few cell types makes them attractive targets for cell-directed therapies. The anti-CD33 (also known as Siglec-3) antibody gemtuzumab (Mylotarg) is approved for the treatment of acute myeloid leukemia, and antibodies targeting CD22 (Siglec-2) are currently in clinical trials for treatment of B cell non-Hodgkins lymphomas and autoimmune diseases. Because siglecs are endocytic receptors, they are well suited for a 'Trojan horse' strategy, whereby therapeutic agents conjugated to an antibody, or multimeric glycan ligand, bind to the siglec and are efficiently carried into the cell. Although the rapid internalization of unmodified siglec antibodies reduces their utility for induction of antibody-dependent cellular cytotoxicity or complement-mediated cytotoxicity, antibody binding of Siglec-8, Siglec-9 and CD22 has been demonstrated to induce apoptosis of eosinophils, neutrophils and depletion of B cells, respectively. Here, we review the properties of siglecs that make them attractive for cell-targeted therapies.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
O'Reilly MK,Paulson JCdoi
10.1016/j.tips.2009.02.005subject
Has Abstractpub_date
2009-05-01 00:00:00pages
240-8issue
5eissn
0165-6147issn
1873-3735pii
S0165-6147(09)00052-2journal_volume
30pub_type
杂志文章,评审abstract：:It has been hypothesized that anxiety disorders play an important role in the initiation and maintenance of alcohol drinking behaviors. However, the molecular mechanisms for the association between anxiety and alcohol abuse are not well understood. Structures of the extended amygdala, particularly the central nucleus ...
journal_title：Trends in pharmacological sciences
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journal_title：Trends in pharmacological sciences
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abstract：:A critical unmet need for treatment of drug-resistant tuberculosis (TB) is to find novel therapies that are efficacious, safe, and shorten the duration of treatment. Drug discovery approaches for TB primarily target essential genes of the pathogen Mycobacterium tuberculosis (Mtb) but novel strategies such as host-dire...
journal_title：Trends in pharmacological sciences
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journal_title：Trends in pharmacological sciences
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更新日期：2013-04-01 00:00:00
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更新日期：2016-05-01 00:00:00
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journal_title：Trends in pharmacological sciences
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更新日期：1995-03-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1016/j.tips.2012.01.004
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更新日期：2012-01-01 00:00:00
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更新日期：2012-04-01 00:00:00
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journal_title：Trends in pharmacological sciences
pub_type： 杂志文章
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更新日期：2006-09-01 00:00:00
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journal_title：Trends in pharmacological sciences
pub_type： 杂志文章,评审
doi：10.1016/s0165-6147(00)88969-5
更新日期：1995-01-01 00:00:00
