Abstract：
:During the past decade, translocator protein 18 kDa (TSPO), previously named peripheral benzodiazepine receptor, has gained a great deal of attention based on its use as a clinical biomarker of neuroinflammation with therapeutic potential. However, there is a paucity of knowledge on the function(s) of TSPO in glial cells. Here, we identify a novel function of TSPO in microglia that is not associated with steroidogenesis. We propose that a TSPO interaction with NADPH oxidase (NOX2) links the generation of reactive oxygen species (ROS) to the induction of an antioxidant response to maintain redox homeostasis. This line of investigation may provide a greater understanding of TSPO glial cell biology, and the knowledge gained may prove beneficial in devising therapeutic strategies.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Guilarte TR,Loth MK,Guariglia SRdoi
10.1016/j.tips.2016.02.008subject
Has Abstractpub_date
2016-05-01 00:00:00pages
334-343issue
5eissn
0165-6147issn
1873-3735pii
S0165-6147(16)00043-2journal_volume
37pub_type
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