TSPO Finds NOX2 in Microglia for Redox Homeostasis.

Abstract:

:During the past decade, translocator protein 18 kDa (TSPO), previously named peripheral benzodiazepine receptor, has gained a great deal of attention based on its use as a clinical biomarker of neuroinflammation with therapeutic potential. However, there is a paucity of knowledge on the function(s) of TSPO in glial cells. Here, we identify a novel function of TSPO in microglia that is not associated with steroidogenesis. We propose that a TSPO interaction with NADPH oxidase (NOX2) links the generation of reactive oxygen species (ROS) to the induction of an antioxidant response to maintain redox homeostasis. This line of investigation may provide a greater understanding of TSPO glial cell biology, and the knowledge gained may prove beneficial in devising therapeutic strategies.

journal_name

Trends Pharmacol Sci

authors

Guilarte TR,Loth MK,Guariglia SR

doi

10.1016/j.tips.2016.02.008

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

334-343

issue

5

eissn

0165-6147

issn

1873-3735

pii

S0165-6147(16)00043-2

journal_volume

37

pub_type

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