Abstract:
:5-Hydroxytryptamine (5-HT), dopamine and norepinephrine are important monoamine neurotransmitters implicated in multiple brain mechanisms and regulated by high-affinity transmembrane monoamine transporters. Although knockout mice lacking 5-HT, dopamine or norepinephrine transporters are widely used to assess brain monoamine processes, these models have several methodological limitations. There is mounting evidence that heterozygous mutant mice with reduced (but not abolished) monoamine transporter functions could provide models with greater relevance to the genetics of human disorders, which only rarely involve complete loss-of-function mutations. Here, we discuss why heterozygous mouse models, in addition to knockout mice, might be useful for brain monoamine transporter research.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Kalueff AV,Ren-Patterson RF,Murphy DLdoi
10.1016/j.tips.2007.01.002subject
Has Abstractpub_date
2007-03-01 00:00:00pages
122-7issue
3eissn
0165-6147issn
1873-3735pii
S0165-6147(07)00021-1journal_volume
28pub_type
杂志文章,评审abstract::Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease and is an important cause of chronic disability. Numerous important advances have been made in our understanding of the aetiopathogenesis, pathology and clinical phenomenology of this disease, and these have underpi...
journal_title:Trends in pharmacological sciences
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doi:10.1016/j.tips.2008.10.005
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journal_title:Trends in pharmacological sciences
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doi:10.1016/0165-6147(90)90009-w
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journal_title:Trends in pharmacological sciences
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