Abstract:
:Recent molecular cloning studies have identified several genes encoding alpha and beta subunits of the nicotinic acetylcholine receptor. These genes have distinct, although overlapping, patterns of expression in the brain and peripheral ganglia. Multiple nicotinic receptors with distinct pharmacological and functional properties can be made in oocytes by pairwise combination of different alpha-type subunits with different beta-type subunits. Both alpha and beta subunits contribute to the pharmacological and functional diversity. Evan Deneris and colleagues explain how oocyte expression studies, in concert with immunological and electrophysiological analysis in vivo, are beginning to reveal the subunit compositions of different neuronal nicotinic receptor subtypes.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Deneris ES,Connolly J,Rogers SW,Duvoisin Rdoi
10.1016/0165-6147(91)90486-csubject
Has Abstractpub_date
1991-01-01 00:00:00pages
34-40issue
1eissn
0165-6147issn
1873-3735pii
0165-6147(91)90486-Cjournal_volume
12pub_type
杂志文章,评审abstract::Chronic inflammation is the basis of various chronic illnesses including cancer and vascular diseases. However, much has yet to be learned how inflammation becomes chronic. Prostaglandins (PGs) are well established as mediators of acute inflammation, and recent studies in experimental animals have provided evidence th...
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