Anti-inflammatory actions of steroids: molecular mechanisms.

Abstract:

:Glucocorticosteroids are highly effective in controlling inflammation and the molecular mechanisms involved are now becoming clear. Activation of glucocorticoid receptors results in increased or decreased transcription of a number of genes involved in the inflammatory process. Of particular importance is the repression of cytokine gene transcription and the direct interaction between the glucocorticoid receptor and other transcription factors activated in chronic inflammation. In this review, Peter Barnes and Ian Adcock discuss recent studies that have increased our understanding of these mechanisms and that may lead to improved anti-inflammatory therapies in the future.

journal_name

Trends Pharmacol Sci

authors

Barnes PJ,Adcock I

doi

10.1016/0165-6147(93)90184-l

subject

Has Abstract

pub_date

1993-12-01 00:00:00

pages

436-41

issue

12

eissn

0165-6147

issn

1873-3735

pii

0165-6147(93)90184-L

journal_volume

14

pub_type

杂志文章,评审
  • The schizophrenic faces of PICK1.

    abstract::Schizophrenia is a grave psychiatric disorder with psychotic symptoms and an enigmatic etiology. Family studies have strongly indicated that genetic risk factors have a role in this disease. Recent findings, together with previously established evidence, highlight the PDZ-domain-containing protein interacting with C-k...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2006.09.007

    authors: Dev KK,Henley JM

    更新日期:2006-11-01 00:00:00

  • Biological and clinical implications of the MTHFR C677T polymorphism.

    abstract::The enzyme methylenetetrahydrofolate reductase (MTHFR) directs folate species either to DNA synthesis or to homocysteine (Hcy) remethylation. The common MTHFR C677T polymorphism affects the activity of the enzyme and hence folate distribution. Under conditions of impaired folate status, the homozygous TT genotype has ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-6147(00)01675-8

    authors: Ueland PM,Hustad S,Schneede J,Refsum H,Vollset SE

    更新日期:2001-04-01 00:00:00

  • Preclinical models of antipsychotic drug-induced metabolic side effects.

    abstract::Antipsychotic drugs (APDs), and the 'atypical' APDs in particular, are commonly associated with metabolic side effects in humans. These include glucose dysregulation, insulin resistance, hyperlipidemia, weight gain and hypertension, which put patients at increased risk of cardiometabolic disorders. The underlying biol...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2010.07.002

    authors: Boyda HN,Tse L,Procyshyn RM,Honer WG,Barr AM

    更新日期:2010-10-01 00:00:00

  • Human cytochromes P450: problems and prospects.

    abstract::Cytochromes P450 are a superfamily of haem-containing monooxygenases. In mammals, two general classes of P450s exist: six families involved in steroid and bile acid biosynthetic pathways of metabolism; four families containing numerous individual P450s, mainly responsible for metabolism of foreign compounds. Many of t...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/0165-6147(92)90107-h

    authors: Gonzalez FJ

    更新日期:1992-09-01 00:00:00

  • Peptides for cell-selective drug delivery.

    abstract::The ability to target specific cell types to achieve optimal distribution of therapeutic entities into diseased tissues, while limiting possible adverse off-target effects, has long been a goal of many research groups and pharmaceutical organizations. This review focuses on peptidic tissue-specific biomarkers that all...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2012.02.002

    authors: Svensen N,Walton JG,Bradley M

    更新日期:2012-04-01 00:00:00

  • Lithium therapy and signal transduction.

    abstract::Lithium is the simplest therapeutic agent available for the treatment of depression and has been used for over 100 years, yet no definitive mechanism for its effect has been established. Among the proposed mechanisms, two lithium-sensitive signal transduction pathways are active in the brain; these are mediated by gly...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/s0165-6147(99)01428-5

    authors: Williams RS,Harwood AJ

    更新日期:2000-02-01 00:00:00

  • Drug-lipid interaction evaluation: why a 19th century solution?

    abstract::The affinity of a drug candidate for a biological membrane (its lipophilicity) is closely related to the pharmacologically crucial events of absorption, biodistribution, metabolization and excretion. The evolution of knowledge of biological membranes during the past two decades contrasts with the rudimentary parameter...

    journal_title:Trends in pharmacological sciences

    pub_type: 历史文章,杂志文章

    doi:10.1016/j.tips.2010.06.007

    authors: Ribeiro MM,Melo MN,Serrano ID,Santos NC,Castanho MA

    更新日期:2010-10-01 00:00:00

  • Biological responses towards cationic peptides and drug carriers.

    abstract::In drug development, major resources are invested into the development of cellular delivery systems to increase the effectiveness of a large array of potential therapeutics, such as proteins and oligonucleotides. These carriers comprise cell-penetrating peptides (CPPs), cationic lipids and cationic polymers. In recent...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2010.11.005

    authors: Verdurmen WP,Brock R

    更新日期:2011-02-01 00:00:00

  • Methylphenidate and cocaine: the same effects on gene regulation?

    abstract::Methylphenidate (Ritalin), a psychostimulant used in the treatment of Attention-Deficit Hyperactivity Disorder, has pharmacological effects similar to cocaine and amphetamine. Clinical use of methylphenidate, as well as diversion and abuse, have significantly increased during the past 10-15 years, heightening concerns...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2007.10.004

    authors: Yano M,Steiner H

    更新日期:2007-11-01 00:00:00

  • Precision Medicine through Antisense Oligonucleotide-Mediated Exon Skipping.

    abstract::Clinical implementation of two recently approved antisense RNA therapeutics - Exondys51® to treat Duchenne muscular dystrophy (Duchenne MD) and Spinraza® as a treatment for spinal muscular atrophy (SMA) - highlights the therapeutic potential of antisense oligonucleotides (ASOs). As shown in the Duchenne and Becker cas...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2018.09.001

    authors: Li D,Mastaglia FL,Fletcher S,Wilton SD

    更新日期:2018-11-01 00:00:00

  • Toxins 'R' Us: more pharmacological tools from nature's superstore.

    abstract::Conus venoms from marine cone snails continue to provide novel bioactive components. Two new classes of conopeptide specifically block alpha(1)-adrenoceptors (rho-conopeptide) and noradrenaline transporters (chi-conopeptides). Both classes are small peptides with two disulfide bonds. Rho-conopeptide is structurally si...

    journal_title:Trends in pharmacological sciences

    pub_type: 新闻

    doi:10.1016/s0165-6147(02)02012-6

    authors: Harvey AL

    更新日期:2002-05-01 00:00:00

  • Historical review: a brief history and personal retrospective of seven-transmembrane receptors.

    abstract::Pharmacologists have studied receptors for more than a century but a molecular understanding of their properties has emerged only during the past 30-35 years. In this article, I provide a personal retrospective of how developments and discoveries primarily during the 1970s and 1980s led to current concepts about the l...

    journal_title:Trends in pharmacological sciences

    pub_type: 历史文章,杂志文章

    doi:10.1016/j.tips.2004.06.006

    authors: Lefkowitz RJ

    更新日期:2004-08-01 00:00:00

  • The pharmacology of apoptosis.

    abstract::Apoptosis is an area of intense scientific interest, which encompasses the study of and triggers mechanisms involved in mediating the cell biology of programmed cell death. A number of low molecular weight compounds have been used to inhibit or enhance this fundamental cellular process and so apoptosis has now become ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-6147(98)01277-2

    authors: Kinloch RA,Treherne JM,Furness LM,Hajimohamadreza I

    更新日期:1999-01-01 00:00:00

  • FAAH and anandamide: is 2-AG really the odd one out?

    abstract::Fatty acid amide hydrolase (FAAH) is a hydrolytic enzyme that recognizes as substrates and inactivates the two most studied endocannabinoids, anandamide and 2-arachidonoylglycerol (2-AG). Following the observation that endocannabinoids produced by tissues during pathological conditions often have protective roles, FAA...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/j.tips.2008.03.001

    authors: Di Marzo V,Maccarrone M

    更新日期:2008-05-01 00:00:00

  • Beyond Cannabis: Plants and the Endocannabinoid System.

    abstract::Plants have been the predominant source of medicines throughout the vast majority of human history, and remain so today outside of industrialized societies. One of the most versatile in terms of its phytochemistry is cannabis, whose investigation has led directly to the discovery of a unique and widespread homeostatic...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2016.04.005

    authors: Russo EB

    更新日期:2016-07-01 00:00:00

  • TSPO Finds NOX2 in Microglia for Redox Homeostasis.

    abstract::During the past decade, translocator protein 18 kDa (TSPO), previously named peripheral benzodiazepine receptor, has gained a great deal of attention based on its use as a clinical biomarker of neuroinflammation with therapeutic potential. However, there is a paucity of knowledge on the function(s) of TSPO in glial ce...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2016.02.008

    authors: Guilarte TR,Loth MK,Guariglia SR

    更新日期:2016-05-01 00:00:00

  • Muscarinic activation of potassium channels in cardiac myocytes: kinetic aspects of G protein function in vivo.

    abstract::Muscarinic agonists open potassium-selective K(ACh) channels in cardiac myocytes of pacemaker or atrial origin. Receptor activation is coupled to channel opening by a membrane bound guanine nucleotide-binding protein (GK) through a process that does not require cytoplasmic intermediates. We have used the muscarinic po...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:

    authors: Szabo G,Otero AS

    更新日期:1989-12-01 00:00:00

  • Discoidin Domains as Emerging Therapeutic Targets.

    abstract::Discoidin (DS) domains are found in eukaryotic and prokaryotic extracellular and transmembrane multidomain proteins. These small domains play different functional roles and can interact with phospholipids, glycans, and proteins, including collagens. DS domain-containing proteins are often involved in cellular adhesion...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2016.06.003

    authors: Villoutreix BO,Miteva MA

    更新日期:2016-08-01 00:00:00

  • Cancer Drug Development Using Drosophila as an in vivo Tool: From Bedside to Bench and Back.

    abstract::The fruit fly Drosophila melanogaster has been used for modeling cancer and as an in vivo tool for the validation and/or development of cancer therapeutics. The impetus for the use of Drosophila in cancer research stems from the high conservation of its signaling pathways, lower genetic redundancy, short life cycle, g...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2016.05.010

    authors: Yadav AK,Srikrishna S,Gupta SC

    更新日期:2016-09-01 00:00:00

  • Chemokines, chemokine receptors and small-molecule antagonists: recent developments.

    abstract::The physiological roles of chemokine receptors have expanded beyond host defense and now represent important targets for intervention in several disease indications. Chemokine receptors have joined the ranks of other members of the G-protein-coupled receptor (GPCR) family in therapeutic potential as small-molecule che...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-6147(02)02064-3

    authors: Onuffer JJ,Horuk R

    更新日期:2002-10-01 00:00:00

  • Techniques: fruit flies as models for neuropharmacological research.

    abstract::An unlikely animal model is gaining popularity in neuropharmacological research: the 2-mm fruit fly (Drosophila melanogaster). Drugs have been administered to adult flies in their food and, more recently, via gasses and injections. Pharmacological tools have introduced behavioral alterations in Drosophila reminiscent ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-6147(02)00004-4

    authors: Manev H,Dimitrijevic N,Dzitoyeva S

    更新日期:2003-01-01 00:00:00

  • Therapeutic approaches to spinal and bulbar muscular atrophy.

    abstract::Spinal and bulbar muscular atrophy is a hereditary motor neuron disease caused by trinucleotide repeat expansion in the androgen receptor gene. The disease mechanism probably involves a toxic gain of function in the mutant protein, because other mutations that cause a loss of androgen receptor function result in a dif...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2010.08.005

    authors: Ranganathan S,Fischbeck KH

    更新日期:2010-11-01 00:00:00

  • GPCR deorphanizations: the novel, the known and the unexpected transmitters.

    abstract::Pairing orphan G-protein-coupled receptors (GPCRs) to potential ligands found in tissue extracts or in libraries of synthetic compounds has identified an ever-increasing number of transmitters, some of which are novel, some of which were previously known and, more recently, some of which are unexpected. These discover...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2004.11.005

    authors: Civelli O

    更新日期:2005-01-01 00:00:00

  • Pharmacological Research as a Key Component in Mitigating the Opioid Overdose Crisis.

    abstract::The United States is experiencing an epidemic of opioid overdose deaths. Many of the recent fatalities are associated with illicitly manufactured fentanyl, which is being added to heroin and counterfeit pain pills. The crisis is further exacerbated by the emergence of an increasing number of novel synthetic opioids (N...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2018.09.006

    authors: Baumann MH,Kopajtic TA,Madras BK

    更新日期:2018-12-01 00:00:00

  • Regulation of mglu(7) receptors by proteins that interact with the intracellular C-terminus.

    abstract::The metabotropic glutamate type 7 (mglu(7)) receptor is a widely distributed, mainly presynaptic Group III mglu receptor that can regulate glutamate release. Recently, largely as a result of the identification of specific proteins that interact with the C-terminal domain of this receptor, considerable progress has bee...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-6147(00)01684-9

    authors: Dev KK,Nakanishi S,Henley JM

    更新日期:2001-07-01 00:00:00

  • Genomic and proteomic strategies to identify novel targets potentially involved in learning and memory.

    abstract::The hippocampus is a crucial player across several learning and memory domains, and is highly vulnerable to alterations during aging. Several products of neurotransmitter genes and neuromodulator genes (which play important parts in mediating and maintaining cognitive ability as a function of age) are expressed in hip...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2010.10.002

    authors: Benoit CE,Rowe WB,Menard C,Sarret P,Quirion R

    更新日期:2011-01-01 00:00:00

  • Place your BETs: the therapeutic potential of bromodomains.

    abstract::Therapeutic targeting of the processes that regulate histone modification is a growing area of scientific exploration. Although most interest has concentrated on the various families of enzymes that contribute to these processes, this review focuses on emerging data demonstrating the chemical tractability and therapeu...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2011.12.002

    authors: Prinjha RK,Witherington J,Lee K

    更新日期:2012-03-01 00:00:00

  • Pharmacological strategies in CNS trauma.

    abstract::Delayed biochemical changes play an important role in tissue damage resulting from traumatic injuries to the central nervous system. Identification of such 'secondary' injury factors has led to the development of various pharmacological strategies aimed at limiting this progressive tissue destruction. In this review, ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/0165-6147(92)90013-v

    authors: Faden AI,Salzman S

    更新日期:1992-01-01 00:00:00

  • Receptor-activated Ca2+ influx: how many mechanisms for how many channels?

    abstract::Receptors that are coupled to the production of inositol (1,4,5)-trisphosphate cause an increase in cytosolic free Ca2+ concentration as a consequence of both Ca2+ mobilization from intracellular stores and Ca2+ influx through the plasma membrane. Although this latter phenomenon appears attributable to the activation ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/0165-6147(94)90282-8

    authors: Fasolato C,Innocenti B,Pozzan T

    更新日期:1994-03-01 00:00:00

  • Epoxyeicosatrienoic Acid as Therapy for Diabetic and Ischemic Cardiomyopathy.

    abstract::Cardiovascular disease remains the leading cause of death worldwide. Among many potential targets for pharmacological intervention, a promising strategy involves epoxyeicosatrienoic acid (EET) and soluble epoxide hydroxylase (sEH) inhibition. sEH is the enzyme that converts EET to its less potent metabolite; therefore...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2016.08.001

    authors: Romashko M,Schragenheim J,Abraham NG,McClung JA

    更新日期:2016-11-01 00:00:00