Abstract:
:For many years the prevailing view of how steroid hormone receptors exert their effects on gene transcription has been that these intracellular receptor proteins, upon association with their specific cognate ligands, undergo a transformation to a state where they are capable of interacting with chromatin and regulating the transcription of specific genes. It has become implicit dogma in the field of biochemical endocrinology that receptor activation is absolutely dependent upon this ligand-binding event. However, recent studies described here by Bert O'Malley and colleagues have shown that certain members of the steroid hormone receptor superfamily can be activated in a totally ligand-independent manner by a cell membrane receptor agonist, the neurotransmitter dopamine.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Power RF,Conneely OM,O'Malley BWdoi
10.1016/0165-6147(92)90099-rsubject
Has Abstractpub_date
1992-08-01 00:00:00pages
318-23issue
8eissn
0165-6147issn
1873-3735pii
0165-6147(92)90099-Rjournal_volume
13pub_type
杂志文章,评审abstract::The affinity of a drug candidate for a biological membrane (its lipophilicity) is closely related to the pharmacologically crucial events of absorption, biodistribution, metabolization and excretion. The evolution of knowledge of biological membranes during the past two decades contrasts with the rudimentary parameter...
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journal_title:Trends in pharmacological sciences
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journal_title:Trends in pharmacological sciences
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journal_title:Trends in pharmacological sciences
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journal_title:Trends in pharmacological sciences
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