Peptides for cell-selective drug delivery.

Abstract:

:The ability to target specific cell types to achieve optimal distribution of therapeutic entities into diseased tissues, while limiting possible adverse off-target effects, has long been a goal of many research groups and pharmaceutical organizations. This review focuses on peptidic tissue-specific biomarkers that allow peptides to act as homing devices for specific tissue types or organs, with a focus on homing peptides (HPs) and cell-penetrating homing peptides (CPHPs). These HPs, in addition to promoting cellular uptake, can deliver a variety of cargos (drugs, oligonucleotides and nanoparticles) into cells. Two such peptides that have entered clinical trials are the tumor-homing peptide asparagine-glycine-arginine (NGR) (fused to human tumor necrosis factor), which selectively binds CD13, an aminopeptidase that is overexpressed on tumor blood vessels, and cyclo[Arg-Gly-Asp-D-Phe-(NMeVal)] (cRGD, cilengitide), an anti-angiogenic agent that targets the α(v)β(3) and α(v)β(5) integrins.

journal_name

Trends Pharmacol Sci

authors

Svensen N,Walton JG,Bradley M

doi

10.1016/j.tips.2012.02.002

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

186-92

issue

4

eissn

0165-6147

issn

1873-3735

pii

S0165-6147(12)00020-X

journal_volume

33

pub_type

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