Functional, molecular and pharmacological advances in 5-HT7 receptor research.

Abstract:

:The 5-HT7 receptor was among a group of 5-HT receptors that were discovered using targeted cloning strategies 12 years ago. This receptor is a seven-transmembrane-domain G-protein-coupled receptor that is positively linked to adenylyl cyclase. The distributions of 5-HT7 receptor mRNA, immunolabeling and radioligand binding exhibit strong similarities, with the highest receptor densities present in the thalamus and hypothalamus and significant densities present in the hippocampus and cortex. The recent availability of selective antagonists and knockout mice strains has dramatically increased our knowledge about this receptor. Together with unselective agonists, these new tools have helped to reveal the 5-HT7 receptor distribution in more detail. Important functional roles for the 5-HT7 receptor in thermoregulation, circadian rhythm, learning and memory, hippocampal signaling and sleep have also been established. Hypotheses driving current research indicate that this receptor might be involved in mood regulation, suggesting that the 5-HT7 receptor is a putative target in the treatment of depression.

journal_name

Trends Pharmacol Sci

authors

Hedlund PB,Sutcliffe JG

doi

10.1016/j.tips.2004.07.002

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

481-6

issue

9

eissn

0165-6147

issn

1873-3735

pii

S0165-6147(04)00185-3

journal_volume

25

pub_type

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