Abstract:
:The 5-HT7 receptor was among a group of 5-HT receptors that were discovered using targeted cloning strategies 12 years ago. This receptor is a seven-transmembrane-domain G-protein-coupled receptor that is positively linked to adenylyl cyclase. The distributions of 5-HT7 receptor mRNA, immunolabeling and radioligand binding exhibit strong similarities, with the highest receptor densities present in the thalamus and hypothalamus and significant densities present in the hippocampus and cortex. The recent availability of selective antagonists and knockout mice strains has dramatically increased our knowledge about this receptor. Together with unselective agonists, these new tools have helped to reveal the 5-HT7 receptor distribution in more detail. Important functional roles for the 5-HT7 receptor in thermoregulation, circadian rhythm, learning and memory, hippocampal signaling and sleep have also been established. Hypotheses driving current research indicate that this receptor might be involved in mood regulation, suggesting that the 5-HT7 receptor is a putative target in the treatment of depression.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Hedlund PB,Sutcliffe JGdoi
10.1016/j.tips.2004.07.002subject
Has Abstractpub_date
2004-09-01 00:00:00pages
481-6issue
9eissn
0165-6147issn
1873-3735pii
S0165-6147(04)00185-3journal_volume
25pub_type
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