Exploring the pharmacological properties of insect nicotinic acetylcholine receptors.

Abstract:

:Insect nicotinic acetylcholine (nACh) receptors are molecular targets of insecticides such as neonicotinoids that are used to control disease-carrying insects and agricultural pests. To date, several insect nACh receptor subunits have been identified, indicating different nACh receptor subtypes and pharmacological profiles. Because of the difficulty in expressing functional insect nACh receptors in heterologous systems, new research tools are needed. Studies on insects resistant to the insecticide imidacloprid and on laboratory-generated hybrid and chimaeric nACh receptors in vitro have provided information about the molecular basis of receptor diversity, neonicotinoid resistance and selectivity. Additionally, recent results indicate that the sensitivity of insect nACh receptors to imidacloprid can be modulated by intracellular phosphorylation mechanisms, which offers a new approach to studying insect nACh receptor pharmacology.

journal_name

Trends Pharmacol Sci

authors

Thany SH,Lenaers G,Raymond-Delpech V,Sattelle DB,Lapied B

doi

10.1016/j.tips.2006.11.006

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

14-22

issue

1

eissn

0165-6147

issn

1873-3735

pii

S0165-6147(06)00271-9

journal_volume

28

pub_type

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