Abstract:
:Insect nicotinic acetylcholine (nACh) receptors are molecular targets of insecticides such as neonicotinoids that are used to control disease-carrying insects and agricultural pests. To date, several insect nACh receptor subunits have been identified, indicating different nACh receptor subtypes and pharmacological profiles. Because of the difficulty in expressing functional insect nACh receptors in heterologous systems, new research tools are needed. Studies on insects resistant to the insecticide imidacloprid and on laboratory-generated hybrid and chimaeric nACh receptors in vitro have provided information about the molecular basis of receptor diversity, neonicotinoid resistance and selectivity. Additionally, recent results indicate that the sensitivity of insect nACh receptors to imidacloprid can be modulated by intracellular phosphorylation mechanisms, which offers a new approach to studying insect nACh receptor pharmacology.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Thany SH,Lenaers G,Raymond-Delpech V,Sattelle DB,Lapied Bdoi
10.1016/j.tips.2006.11.006subject
Has Abstractpub_date
2007-01-01 00:00:00pages
14-22issue
1eissn
0165-6147issn
1873-3735pii
S0165-6147(06)00271-9journal_volume
28pub_type
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