Abstract:
:Over the past few decades, mortality resulting from cardiovascular disease (CVD) steadily decreased in western countries; however, in recent years, the decline has become offset by the increase in obesity. Obesity is strongly associated with the metabolic syndrome and its atherogenic dyslipidemia resulting from insulin resistance. While lifestyle treatment would be effective, drugs targeting individual risk factors are often required. Such treatment may result in polypharmacy. Novel approaches are directed towards the treatment of several risk factors with one drug. Studies in animal models and humans suggest a central role for sterol regulatory-element binding proteins (SREBPs) in the pathophysiology of the metabolic syndrome. Four recent studies targeting the maturation or transcriptional activities of SREBPs provide proof of concept for the efficacy of SREBP inhibition in this syndrome.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Soyal SM,Nofziger C,Dossena S,Paulmichl M,Patsch Wdoi
10.1016/j.tips.2015.04.010subject
Has Abstractpub_date
2015-06-01 00:00:00pages
406-16issue
6eissn
0165-6147issn
1873-3735pii
S0165-6147(15)00086-3journal_volume
36pub_type
杂志文章,评审abstract::Cannabis (marijuana) is not only a frequently abused drug but also has the potential for the development of useful agents for the treatment of emesis, anorexia and multiple sclerosis. In this article, the effects of modulation of transmitter release by cannabinoids in both the CNS and the PNS of various species, inclu...
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