The schizophrenic faces of PICK1.

Abstract:

:Schizophrenia is a grave psychiatric disorder with psychotic symptoms and an enigmatic etiology. Family studies have strongly indicated that genetic risk factors have a role in this disease. Recent findings, together with previously established evidence, highlight the PDZ-domain-containing protein interacting with C-kinase 1 (PICK1) as a promising candidate for a schizophrenia susceptibility gene. Here, we outline possible molecular mechanisms, discuss clinical case-studies that indicate an unexpected role of PICK1 in schizophrenia and discuss potential avenues for pharmacological manipulation of PICK1.

journal_name

Trends Pharmacol Sci

authors

Dev KK,Henley JM

doi

10.1016/j.tips.2006.09.007

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

574-9

issue

11

eissn

0165-6147

issn

1873-3735

pii

S0165-6147(06)00227-6

journal_volume

27

pub_type

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