Abstract：
:K(+) channels are macromolecules embedded in biological membranes, where they play a key role in cellular excitability and signal transduction pathways. Knowledge of their structure should help improve our understanding of their function and lead to the design of therapeutic compounds. Most pharmacological and structural characteristics of these channels have been elucidated by using high-affinity channel blockers isolated from scorpion venoms. Recent data on the three-dimensional structures of K(+) channels and novel scorpion toxins suggest a variety of novel interacting modes of these channels and toxins, which should help increase our understanding of the K(+) channel structure-function relationship.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Rodríguez de la Vega RC,Merino E,Becerril B,Possani LDdoi
10.1016/S0165-6147(03)00080-4subject
Has Abstractpub_date
2003-05-01 00:00:00pages
222-7issue
5eissn
0165-6147issn
1873-3735pii
S0165-6147(03)00080-4journal_volume
24pub_type
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