How and why do GPCRs dimerize?

Abstract:

:Dimerization is fairly common in the G-protein-coupled receptor (GPCR) superfamily. First attempts to rationalize this phenomenon gave rise to an idea that two receptors in a dimer could be necessary to bind a single molecule of G protein or arrestin. Although GPCRs, G proteins and arrestins were crystallized only in their inactive conformations (in which they do not interact), the structures appeared temptingly compatible with this beautiful model. However, it did not survive the rigors of experimental testing: several recent studies unambiguously demonstrated that one receptor molecule is sufficient to activate a G protein and bind arrestin. Thus, to figure out the biological role of receptor self-association we must focus on other functions of GPCRs at different stages of their functional cycle.

journal_name

Trends Pharmacol Sci

authors

Gurevich VV,Gurevich EV

doi

10.1016/j.tips.2008.02.004

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

234-40

issue

5

eissn

0165-6147

issn

1873-3735

pii

S0165-6147(08)00069-2

journal_volume

29

pub_type

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