Abstract:
:Annexin A1 (ANXA1) is an endogenous protein known to have potent anti-inflammatory properties in the peripheral system. It has also been detected in the brain, but its function there is still ambiguous. In this review, we have, for the first time, collated the evidence currently available on the function of ANXA1 in the brain and have proposed several possible mechanisms by which it exerts a neuroprotective or anti-neuroinflammatory function. We suggest that ANXA1, its small peptide mimetics and its receptors might be exciting new therapeutic targets in the management of a wide range of neuroinflammatory diseases, including stroke and neurodegenerative conditions.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Solito E,McArthur S,Christian H,Gavins F,Buckingham JC,Gillies GEdoi
10.1016/j.tips.2007.12.003subject
Has Abstractpub_date
2008-03-01 00:00:00pages
135-42issue
3eissn
0165-6147issn
1873-3735pii
S0165-6147(08)00020-5journal_volume
29pub_type
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