Abstract：
:Receptors that are coupled to the production of inositol (1,4,5)-trisphosphate cause an increase in cytosolic free Ca2+ concentration as a consequence of both Ca2+ mobilization from intracellular stores and Ca2+ influx through the plasma membrane. Although this latter phenomenon appears attributable to the activation of a number of Ca(2+)-permeable channels, the channels that are controlled by the Ca2+ content of the intracellular stores have recently received much attention. In this review, Cristina Fasolato, Barbara Innocenti and Tullio Pozzan summarize the characteristics of this Ca(2+)-influx pathway and discuss the hypotheses about its mechanism of activation and its relationship with other receptor-activated Ca2+ channels.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Fasolato C,Innocenti B,Pozzan Tdoi
10.1016/0165-6147(94)90282-8subject
Has Abstractpub_date
1994-03-01 00:00:00pages
77-83issue
3eissn
0165-6147issn
1873-3735pii
0165-6147(94)90282-8journal_volume
15pub_type
杂志文章,评审abstract：:Lithium is the simplest therapeutic agent available for the treatment of depression and has been used for over 100 years, yet no definitive mechanism for its effect has been established. Among the proposed mechanisms, two lithium-sensitive signal transduction pathways are active in the brain; these are mediated by gly...
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journal_title：Trends in pharmacological sciences
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