Receptor-activated Ca2+ influx: how many mechanisms for how many channels?

Abstract:

:Receptors that are coupled to the production of inositol (1,4,5)-trisphosphate cause an increase in cytosolic free Ca2+ concentration as a consequence of both Ca2+ mobilization from intracellular stores and Ca2+ influx through the plasma membrane. Although this latter phenomenon appears attributable to the activation of a number of Ca(2+)-permeable channels, the channels that are controlled by the Ca2+ content of the intracellular stores have recently received much attention. In this review, Cristina Fasolato, Barbara Innocenti and Tullio Pozzan summarize the characteristics of this Ca(2+)-influx pathway and discuss the hypotheses about its mechanism of activation and its relationship with other receptor-activated Ca2+ channels.

journal_name

Trends Pharmacol Sci

authors

Fasolato C,Innocenti B,Pozzan T

doi

10.1016/0165-6147(94)90282-8

subject

Has Abstract

pub_date

1994-03-01 00:00:00

pages

77-83

issue

3

eissn

0165-6147

issn

1873-3735

pii

0165-6147(94)90282-8

journal_volume

15

pub_type

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