Abstract：
:Drug development consumes huge amounts of time and money and the search for novel analgesics, which are urgently required, is particularly difficult, having resulted in many setbacks in the past. Drug repurposing - the identification of new uses for existing drugs - is an alternative approach, which bypasses most of the time- and cost-consuming components of drug development. Recent, unexpected findings suggest a role for several existing drugs, such as minocycline, ceftriaxone, sivelestat, and pioglitazone, as novel analgesics in chronic and neuropathic pain states. Here, we discuss these findings as well as their proposed antihyperalgesic mechanisms and outline the merits of pathway-based repurposing screens, in combination with bioinformatics and novel cellular reprogramming techniques, for the identification of novel analgesics.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Sisignano M,Parnham MJ,Geisslinger Gdoi
10.1016/j.tips.2015.11.006subject
Has Abstractpub_date
2016-03-01 00:00:00pages
172-183issue
3eissn
0165-6147issn
1873-3735pii
S0165-6147(15)00242-4journal_volume
37pub_type
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