Kill 'Em All: Efgartigimod Immunotherapy for Autoimmune Diseases.

Abstract:

:Neonatal Fc receptors (FcRns) recycle IgGs by preventing their lysosome degradation. As this process also enhances half-life of pathogenic auto-IgG, inspired from the mechanisms of intravenous immunoglobulin, several inhibitors of IgG-FcRn interface have been conceived for treating autoimmune diseases. Among them, the high-affinity FcRn-binding engineered Fc molecule efgartigimod has recently completed phase I clinical trial.

journal_name

Trends Pharmacol Sci

authors

Bayry J,Kaveri SV

doi

10.1016/j.tips.2018.08.004

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

919-922

issue

11

eissn

0165-6147

issn

1873-3735

pii

S0165-6147(18)30139-1

journal_volume

39

pub_type

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