Stress, hormonal changes, alcohol, food constituents and drugs: factors that advance the incidence of tobacco smoke-related cancer?

Abstract:

:The genotoxicity of the most potent carcinogen in cigarette smoke [4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)] is dependent on the relationship between its activation by cytochrome P450 enzymes and its detoxification by carbonyl reduction to NNK alcohol (NNAL) followed by glucuronidation. Recently, '11 beta-hydroxysteroid dehydrogenase' (11 beta-HSD 1) was identified to be responsible for NNK carbonyl reduction. It is now speculated that differences in tissue expression of 11 beta-HSD 1, as well as genetic polymorphisms, may have profound influences on the organospecificity and potency of NNK-induced cancerogenesis. Moreover, endogenous and exogenous substrates or inhibitors of 11 beta-HSD 1 may shift the NNK/NNAL equilibrium and favour NNK toxification in a variety of physiological and therapeutic situations. These issues are discussed here by Edmund Maser, who also describes how recent observations could provide the experimental base for epidemiological or clinical studies, which focus on polymorphisms in 11 beta-HSD 1 enzyme expression, as well as on implications of exposure to 11 beta-HSD 1 modulators and concurrent smoking.

journal_name

Trends Pharmacol Sci

authors

Maser E

doi

10.1016/s0165-6147(97)01090-0

subject

Has Abstract

pub_date

1997-08-01 00:00:00

pages

270-5

issue

8

eissn

0165-6147

issn

1873-3735

pii

S0165-6147(97)01090-0

journal_volume

18

pub_type

杂志文章,评审
  • Size matters in activation/inhibition of ligand-gated ion channels.

    abstract::Cys loop, glutamate, and P2X receptors are ligand-gated ion channels (LGICs) with 5, 4, and 3 protomers, respectively. There is now growing atomic level understanding of their gating mechanisms. Although each family is unique in the architecture of the ligand-binding pocket, the pathway for motions to propagate from l...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2012.06.005

    authors: Du J,Dong H,Zhou HX

    更新日期:2012-09-01 00:00:00

  • FAAH and anandamide: is 2-AG really the odd one out?

    abstract::Fatty acid amide hydrolase (FAAH) is a hydrolytic enzyme that recognizes as substrates and inactivates the two most studied endocannabinoids, anandamide and 2-arachidonoylglycerol (2-AG). Following the observation that endocannabinoids produced by tissues during pathological conditions often have protective roles, FAA...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/j.tips.2008.03.001

    authors: Di Marzo V,Maccarrone M

    更新日期:2008-05-01 00:00:00

  • Structural insights into adrenergic receptor function and pharmacology.

    abstract::It has been over 50years since Sir James Black developed the first beta adrenergic receptor (βAR) blocker to treat heart disease. At that time, the concept of cell surface receptors was relatively new and not widely accepted, and most of the tools currently used to characterize plasma membrane receptors had not been d...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2011.02.005

    authors: Kobilka BK

    更新日期:2011-04-01 00:00:00

  • Using genotyping to predict responses to anti-hypertensive treatment.

    abstract::Hypertension is prevalent and affects approximately 1 in every 4 adults in the Western world. Although many drugs are effective in treating hypertension, an individual's response to treatment is unpredictable. Pharmacogenetics holds the promise of becoming a tool to predict this response but obstacles and shortcomings...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/j.tips.2005.07.008

    authors: Kurland L,Lind L,Melhus H

    更新日期:2005-09-01 00:00:00

  • Drug Repurposing for the Development of Novel Analgesics.

    abstract::Drug development consumes huge amounts of time and money and the search for novel analgesics, which are urgently required, is particularly difficult, having resulted in many setbacks in the past. Drug repurposing - the identification of new uses for existing drugs - is an alternative approach, which bypasses most of t...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/j.tips.2015.11.006

    authors: Sisignano M,Parnham MJ,Geisslinger G

    更新日期:2016-03-01 00:00:00

  • Higher-order organization and regulation of adenylyl cyclases.

    abstract::There is increasing awareness of the compartmentalization of cAMP signalling--the means by which cAMP levels change in discrete domains of the cell with discrete local consequences. Current developments in understanding the organization of adenylyl cyclases in the plasma membrane are illuminating how the earliest part...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2006.06.002

    authors: Cooper DM,Crossthwaite AJ

    更新日期:2006-08-01 00:00:00

  • Drugging unconventional targets: insights from Huntington's disease.

    abstract::Classical targeted drug discovery is based on targeting druggable targets, typically kinases and receptors of which the function can be agonized or antagonized. This strategy meets difficulties in cases such as Huntington's disease (HD) and similar neurodegenerative disorders, where the pathological function of the pr...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2013.12.001

    authors: Yu S,Liang Y,Palacino J,Difiglia M,Lu B

    更新日期:2014-02-01 00:00:00

  • 5-HT2 receptor subtypes: a family re-united?

    abstract::The current classification for 5-HT2 receptors accommodates three subtypes. In addition to the originally defined 5-HT2 receptor, sanctuary is now provided for the structurally related 5-HT1c receptor (now 5-HT2c) and at least one atypical 5-HT receptor subtype. The strong functional union of this family is reflected ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-6147(00)88991-9

    authors: Baxter G,Kennett G,Blaney F,Blackburn T

    更新日期:1995-03-01 00:00:00

  • Are formyl peptide receptors novel targets for therapeutic intervention in ischaemia-reperfusion injury?

    abstract::Ischaemia-reperfusion (I/R) injury is a common feature of several diseases associated with high morbidity and mortality, such as stroke and myocardial infarction. The damaged tissue displays cardinal signs of inflammation and microvascular injury that, unless resolved, lead to long-term tissue damage with associated d...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2010.04.001

    authors: Gavins FN

    更新日期:2010-06-01 00:00:00

  • The sigma-1 receptor chaperone as an inter-organelle signaling modulator.

    abstract::Inter-organelle signaling plays important roles in many physiological functions. Endoplasmic reticulum (ER)-mitochondrion signaling affects intramitochondrial calcium (Ca(2+)) homeostasis and cellular bioenergetics. ER-nucleus signaling attenuates ER stress. ER-plasma membrane signaling regulates cytosolic Ca(2+) home...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/j.tips.2010.08.007

    authors: Su TP,Hayashi T,Maurice T,Buch S,Ruoho AE

    更新日期:2010-12-01 00:00:00

  • GPCR deorphanizations: the novel, the known and the unexpected transmitters.

    abstract::Pairing orphan G-protein-coupled receptors (GPCRs) to potential ligands found in tissue extracts or in libraries of synthetic compounds has identified an ever-increasing number of transmitters, some of which are novel, some of which were previously known and, more recently, some of which are unexpected. These discover...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2004.11.005

    authors: Civelli O

    更新日期:2005-01-01 00:00:00

  • The developing use of heterozygous mutant mouse models in brain monoamine transporter research.

    abstract::5-Hydroxytryptamine (5-HT), dopamine and norepinephrine are important monoamine neurotransmitters implicated in multiple brain mechanisms and regulated by high-affinity transmembrane monoamine transporters. Although knockout mice lacking 5-HT, dopamine or norepinephrine transporters are widely used to assess brain mon...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2007.01.002

    authors: Kalueff AV,Ren-Patterson RF,Murphy DL

    更新日期:2007-03-01 00:00:00

  • Comparing nuclear receptors in worms, flies and humans.

    abstract::Complete nucleotide sequences are now available for different species of the animal kingdom: Caenorhabditis elegans - a nematode, Drosophila - an insect, and humans - a mammal. Such information makes it possible to compare the set of nuclear receptors found in these organisms, and to discuss the possible reasons for t...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-6147(00)01859-9

    authors: Enmark E,Gustafsson JA

    更新日期:2001-12-01 00:00:00

  • Pharmacological tools for the development of traditional Chinese medicine.

    abstract::Pharmacology as a modern science was introduced in China approximately 150 years ago, and has been used since then to study traditional Chinese medicine (TCM). Pharmacology has experienced its own development over this time and continues to provide new tools for the study of TCM. In the present review, three models fo...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2013.09.004

    authors: Liu X,Wu WY,Jiang BH,Yang M,Guo DA

    更新日期:2013-11-01 00:00:00

  • Clodronate: A Vesicular ATP Release Blocker.

    abstract::Clodronate is a first-generation bisphosphonate used worldwide for antiresorptive therapy for osteoporosis. Although clodronate is analgesic in nature, its mechanism and efficacy were unknown for some time. Recently, clodronate was identified as a selective and potent inhibitor for vesicular nucleotide transporter (VN...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2017.10.007

    authors: Moriyama Y,Nomura M

    更新日期:2018-01-01 00:00:00

  • The benzodiazepine binding site of GABAA receptors.

    abstract::The GABAA receptor belongs, along with the nicotinic acetylcholine receptor, the glycine receptor and the 5-HT3 receptor, to a family of homologous transmitter-gated ion channels mediating fast synaptic transmission. Many classes of drug interact with the GABAA receptor, which is the major inhibitory ion channel in th...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-6147(97)01118-8

    authors: Sigel E,Buhr A

    更新日期:1997-11-01 00:00:00

  • Techniques: reporter mice - a new way to look at drug action.

    abstract::During the past decade remarkable progress in molecular genetics and the possibility of manipulating cells so that the expression of genes can directly 'report' on drug activity has produced major changes in drug development strategies. The recent description and pharmacological validation of reporter mice for in vivo...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2004.04.007

    authors: Maggi A,Ottobrini L,Biserni A,Lucignani G,Ciana P

    更新日期:2004-06-01 00:00:00

  • Therapeutic potential of histamine H3 receptor agonists and antagonists.

    abstract::The histamine H3 receptor was discovered 15 years ago, and many potent and selective H3 receptor agonists and antagonists have since been developed. Currently, much attention is being focused on the therapeutic potential of H3 receptor ligands. In this review, Rob Leurs, Patrizio Blandina, Clark Tedford and Henk Timme...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-6147(98)01201-2

    authors: Leurs R,Blandina P,Tedford C,Timmerman H

    更新日期:1998-05-01 00:00:00

  • Phosphodiesterases reduce spontaneous sinoatrial beating but not the 'fight or flight' tachycardia elicited by agonists through Gs-protein-coupled receptors.

    abstract::Cyclic AMP (cAMP) steers the generation of basal heart beat in the sinoatrial node. It also induces sinoatrial tachycardia and increased cardiac force, elicited through activation of Gs-protein-coupled receptors (GsPCRs). Phosphodiesterases (PDEs) hydrolyse cAMP. In the heart mainly PDE3 and PDE4 would be expected to ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/j.tips.2011.03.003

    authors: Kaumann AJ

    更新日期:2011-07-01 00:00:00

  • Biological Evidence for Paradoxical Improvement of Psychiatric Disorder Symptoms by Addictive Drugs.

    abstract::Addiction biology has focused on the mechanisms of the positive and negative reinforcing actions of addictive drugs but neglected potential benefits. Two new studies provide the first insights into a neurobiology of psychoactive drug instrumentalization. This may help us design better models for addiction neuroscience...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/j.tips.2017.03.005

    authors: Müller CP,Kornhuber J

    更新日期:2017-06-01 00:00:00

  • Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria.

    abstract::Drugs that cause liver injury often 'stress' mitochondria and activate signal transduction pathways important in determining cell survival or death. In most cases, hepatocytes adapt to the drug-induced stress by activating adaptive signaling pathways, such as mitochondrial adaptive responses and nuclear factor erythro...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2013.01.009

    authors: Han D,Dara L,Win S,Than TA,Yuan L,Abbasi SQ,Liu ZX,Kaplowitz N

    更新日期:2013-04-01 00:00:00

  • Selective and mixed endothelin receptor antagonism in cardiovascular disease.

    abstract::Within five years of discovering endothelin (ET-1) in 1988, the first report of an orally available ET receptor antagonist was published. Within twelve years, bosentan, the first ET receptor antagonist to gain marketing authorization, was made available for the treatment of pulmonary artery hypertension (PAH). Since t...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2007.10.002

    authors: Dhaun N,Pollock DM,Goddard J,Webb DJ

    更新日期:2007-11-01 00:00:00

  • The 'ABC' of GABA receptors.

    abstract::In the conventional view, GABA acts at either ionotropic GABAA or metabotropic GABAB receptors. Recently, novel ionotropic GABA receptors that are composed of rho-subunits have been identified in the vertebrate retina. These bicuculline- and baclofen-insensitive GABA receptors are frequently called GABAC, following an...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-6147(99)01413-3

    authors: Bormann J

    更新日期:2000-01-01 00:00:00

  • Frizzleds as GPCRs - More Conventional Than We Thought!

    abstract::For more than 30 years, WNT/β-catenin and planar cell polarity signaling has formed the basis for what we understand to be the primary output of the interaction between WNTs and their cognate receptors known as Frizzleds (FZDs). In the shadow of these pathways, evidence for the involvement of heterotrimeric G proteins...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2018.07.001

    authors: Schulte G,Wright SC

    更新日期:2018-09-01 00:00:00

  • Does the pharmacology of oxycodone justify its increasing use as an analgesic?

    abstract::Oxycodone is a semisynthetic opioid analgesic that is increasingly used for the treatment of acute, cancer, and chronic non-malignant pain. Oxycodone was synthesized in 1917 but its pharmacological properties were not thoroughly studied until recently. Oxycodone is a fairly selective μ-opioid receptor agonist, but the...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2013.02.001

    authors: Olkkola KT,Kontinen VK,Saari TI,Kalso EA

    更新日期:2013-04-01 00:00:00

  • Suppressing production of reactive oxygen species (ROS) for influenza A virus therapy.

    abstract::Influenza A viral infections claim millions of lives worldwide and continue to impose a major burden on healthcare systems. Current pharmacological strategies to control influenza A virus-induced lung disease are problematic owing to antiviral resistance and the requirement for strain-specific vaccination. The product...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2011.09.001

    authors: Vlahos R,Stambas J,Selemidis S

    更新日期:2012-01-01 00:00:00

  • Unveiling the role of network and systems biology in drug discovery.

    abstract::Network and systems biology offer a novel way of approaching drug discovery by developing models that consider the global physiological environment of protein targets, and the effects of modifying them, without losing the key molecular details. Here we review some recent advances in network and systems biology applied...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2009.11.006

    authors: Pujol A,Mosca R,Farrés J,Aloy P

    更新日期:2010-03-01 00:00:00

  • Precision Medicine through Antisense Oligonucleotide-Mediated Exon Skipping.

    abstract::Clinical implementation of two recently approved antisense RNA therapeutics - Exondys51® to treat Duchenne muscular dystrophy (Duchenne MD) and Spinraza® as a treatment for spinal muscular atrophy (SMA) - highlights the therapeutic potential of antisense oligonucleotides (ASOs). As shown in the Duchenne and Becker cas...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2018.09.001

    authors: Li D,Mastaglia FL,Fletcher S,Wilton SD

    更新日期:2018-11-01 00:00:00

  • Of mice and flies: commonalities among 5-HT receptors.

    abstract::Pharmacological studies as well as molecular cloning of 5-HT receptors have revealed a multiplicity of receptor subtypes, not only in mammals but, as discussed in this review by René Hen, also in molluscs and arthropods. Most of these receptors belong to the G protein-coupled receptor family, and their mechanism of ac...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/0165-6147(92)90054-a

    authors: Hen R

    更新日期:1992-04-01 00:00:00

  • Neuroprotective strategies for Parkinson's disease: conceptual limits of animal models and clinical trials.

    abstract::Parkinson's disease (PD) is a progressive neurodegenerative disorder. Although therapies that treat the symptoms of the disease have proven efficacy, strategies that slow or stop the neurodegenerative process are currently not available. Recently, the National Institute of Neurological Disorders and Stroke (NINDS) con...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2004.03.003

    authors: Meissner W,Hill MP,Tison F,Gross CE,Bezard E

    更新日期:2004-05-01 00:00:00