Heat Shock Proteins and Cancer.

Abstract:

:Heat shock proteins (HSPs) constitute a large family of proteins involved in protein folding and maturation whose expression is induced by heat shock or other stressors. The major groups are classified based on their molecular weights and include HSP27, HSP40, HSP60, HSP70, HSP90, and large HSPs. HSPs play a significant role in cellular proliferation, differentiation, and carcinogenesis. In this article we comprehensively review the roles of major HSPs in cancer biology and pharmacology. HSPs are thought to play significant roles in the molecular mechanisms leading to cancer development and metastasis. HSPs may also have potential clinical uses as biomarkers for cancer diagnosis, for assessing disease progression, or as therapeutic targets for cancer therapy.

journal_name

Trends Pharmacol Sci

authors

Wu J,Liu T,Rios Z,Mei Q,Lin X,Cao S

doi

10.1016/j.tips.2016.11.009

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

226-256

issue

3

eissn

0165-6147

issn

1873-3735

pii

S0165-6147(16)30167-5

journal_volume

38

pub_type

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