Heat Shock Proteins and Cancer.


:Heat shock proteins (HSPs) constitute a large family of proteins involved in protein folding and maturation whose expression is induced by heat shock or other stressors. The major groups are classified based on their molecular weights and include HSP27, HSP40, HSP60, HSP70, HSP90, and large HSPs. HSPs play a significant role in cellular proliferation, differentiation, and carcinogenesis. In this article we comprehensively review the roles of major HSPs in cancer biology and pharmacology. HSPs are thought to play significant roles in the molecular mechanisms leading to cancer development and metastasis. HSPs may also have potential clinical uses as biomarkers for cancer diagnosis, for assessing disease progression, or as therapeutic targets for cancer therapy.


Trends Pharmacol Sci


Wu J,Liu T,Rios Z,Mei Q,Lin X,Cao S




Has Abstract


2017-03-01 00:00:00














  • Structural insights into adrenergic receptor function and pharmacology.

    abstract::It has been over 50years since Sir James Black developed the first beta adrenergic receptor (βAR) blocker to treat heart disease. At that time, the concept of cell surface receptors was relatively new and not widely accepted, and most of the tools currently used to characterize plasma membrane receptors had not been d...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Kobilka BK

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  • Protein kinase Calpha: disease regulator and therapeutic target.

    abstract::Protein kinase Calpha (PKCalpha) is a member of the AGC (which includes PKD, PKG and PKC) family of serine/threonine protein kinases that is widely expressed in mammalian tissues. It is closely related in structure, function and regulation to other members of the protein kinase C family, but has specific functions wit...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Konopatskaya O,Poole AW

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  • Higher-order organization and regulation of adenylyl cyclases.

    abstract::There is increasing awareness of the compartmentalization of cAMP signalling--the means by which cAMP levels change in discrete domains of the cell with discrete local consequences. Current developments in understanding the organization of adenylyl cyclases in the plasma membrane are illuminating how the earliest part...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Cooper DM,Crossthwaite AJ

    更新日期:2006-08-01 00:00:00

  • The 'ABC' of GABA receptors.

    abstract::In the conventional view, GABA acts at either ionotropic GABAA or metabotropic GABAB receptors. Recently, novel ionotropic GABA receptors that are composed of rho-subunits have been identified in the vertebrate retina. These bicuculline- and baclofen-insensitive GABA receptors are frequently called GABAC, following an...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Bormann J

    更新日期:2000-01-01 00:00:00

  • Modulation of transmitter release via presynaptic cannabinoid receptors.

    abstract::Cannabis (marijuana) is not only a frequently abused drug but also has the potential for the development of useful agents for the treatment of emesis, anorexia and multiple sclerosis. In this article, the effects of modulation of transmitter release by cannabinoids in both the CNS and the PNS of various species, inclu...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Schlicker E,Kathmann M

    更新日期:2001-11-01 00:00:00

  • Pharmacological strategies in CNS trauma.

    abstract::Delayed biochemical changes play an important role in tissue damage resulting from traumatic injuries to the central nervous system. Identification of such 'secondary' injury factors has led to the development of various pharmacological strategies aimed at limiting this progressive tissue destruction. In this review, ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Faden AI,Salzman S

    更新日期:1992-01-01 00:00:00

  • Biological and clinical implications of the MTHFR C677T polymorphism.

    abstract::The enzyme methylenetetrahydrofolate reductase (MTHFR) directs folate species either to DNA synthesis or to homocysteine (Hcy) remethylation. The common MTHFR C677T polymorphism affects the activity of the enzyme and hence folate distribution. Under conditions of impaired folate status, the homozygous TT genotype has ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Ueland PM,Hustad S,Schneede J,Refsum H,Vollset SE

    更新日期:2001-04-01 00:00:00

  • Non-genomic loss of PTEN function in cancer: not in my genes.

    abstract::Loss of function of the phosphatase and tensin homolog (PTEN) tumour suppressor contributes to the development of many cancers. However, in contrast to classical models of tumour suppression, partial loss of PTEN function appears to be frequently observed in the clinic. In addition, studies of both humans and mice wit...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Leslie NR,Foti M

    更新日期:2011-03-01 00:00:00

  • Does the ternary complex act as a secondary proton pump and a GTP synthase?

    abstract::It has been suggested that G protein-coupled receptors can act as proton transporters, with the activated G protein-coupled receptor transporting H+ across the membrane from the extracellular side to the cytoplasm. In this article, Paul Nederkoorn, Henk Timmerman and Gabriëlle Donné-Op den Kelder summarize the various...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Nederkoorn PH,Timmerman H,Donné-Op den Kelder GM

    更新日期:1995-05-01 00:00:00

  • Do cannabinoids have a therapeutic role in transplantation?

    abstract::Cannabinoids have emerged as powerful drug candidates for the treatment of inflammatory and autoimmune diseases due to their immunosuppressive properties. Significant clinical and experimental data on the use of cannabinoids as anti-inflammatory agents exist in many autoimmune disease settings, but virtually no studie...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Nagarkatti M,Rieder SA,Hegde VL,Kanada S,Nagarkatti P

    更新日期:2010-08-01 00:00:00

  • Axons Matter: The Promise of Treating Neurodegenerative Disorders by Targeting SARM1-Mediated Axonal Degeneration.

    abstract::Attempts to develop neuroprotective treatments for neurodegenerative disorders have not yet been clinically successful. Axonal degeneration has been recognized as a predominant driver of disability and disease progression in central nervous system (CNS) diseases such as amyotrophic lateral sclerosis (ALS), multiple sc...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Krauss R,Bosanac T,Devraj R,Engber T,Hughes RO

    更新日期:2020-04-01 00:00:00

  • Nematode genome sequence dramatically extends the nuclear receptor superfamily.

    abstract::Nuclear receptors represent a large class of ligand-activated transcriptional regulators; about 70 members of this protein family have been cloned from mammalian or insect species. Thus, it came as a great surprise when the recent completion of the Caenorhabditis elegans genome revealed at least 228 genes for nuclear ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Enmark E,Gustafsson JA

    更新日期:2000-03-01 00:00:00

  • Regulation of free calmodulin levels by neuromodulin: neuron growth and regeneration.

    abstract::Neuromodulin is a neurospecific calmodulin binding protein that is implicated in neurite extension, axonal elongation and long-term potentiation. Yuechueng Liu and Daniel Storm propose that neuromodulin binds and concentrates calmodulin on growth cone membranes and that stimulation of protein kinase C releases high lo...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Liu YC,Storm DR

    更新日期:1990-03-01 00:00:00

  • Targeting GLI factors to inhibit the Hedgehog pathway.

    abstract::Hedgehog (Hh) signaling has emerged in recent years as an attractive target for anticancer therapy because its aberrant activation is implicated in several cancers. Major progress has been made in the development of SMOOTHENED (SMO) antagonists, although they have shown several limitations due to downstream SMO pathwa...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Infante P,Alfonsi R,Botta B,Mori M,Di Marcotullio L

    更新日期:2015-08-01 00:00:00

  • Exploring the potential of adjunct therapy in tuberculosis.

    abstract::A critical unmet need for treatment of drug-resistant tuberculosis (TB) is to find novel therapies that are efficacious, safe, and shorten the duration of treatment. Drug discovery approaches for TB primarily target essential genes of the pathogen Mycobacterium tuberculosis (Mtb) but novel strategies such as host-dire...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Rayasam GV,Balganesh TS

    更新日期:2015-08-01 00:00:00

  • FAAH and anandamide: is 2-AG really the odd one out?

    abstract::Fatty acid amide hydrolase (FAAH) is a hydrolytic enzyme that recognizes as substrates and inactivates the two most studied endocannabinoids, anandamide and 2-arachidonoylglycerol (2-AG). Following the observation that endocannabinoids produced by tissues during pathological conditions often have protective roles, FAA...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章


    authors: Di Marzo V,Maccarrone M

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  • Ethanol tolerance and synaptic plasticity.

    abstract::Current concepts of the mechanisms underlying many of the pharmacological effects of ethanol on the CNS involve disruption of ion channel function via the interaction of ethanol with specific hydrophobic sites on channel subunit proteins. Of particular clinical importance is the development of tolerance and dependence...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Chandler LJ,Harris RA,Crews FT

    更新日期:1998-12-01 00:00:00

  • Targeting PAR1: Now What?

    abstract::Protease-activated receptors (PARs) are a ubiquitously expressed class of G-protein-coupled receptors (GPCRs) that enable cells to respond to proteases in the extracellular environment in a nuanced and dynamic manner. PAR1 is the archetypal family member and has been the object of large-scale drug development programs...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Flaumenhaft R,De Ceunynck K

    更新日期:2017-08-01 00:00:00

  • 5-HT2 receptor subtypes: a family re-united?

    abstract::The current classification for 5-HT2 receptors accommodates three subtypes. In addition to the originally defined 5-HT2 receptor, sanctuary is now provided for the structurally related 5-HT1c receptor (now 5-HT2c) and at least one atypical 5-HT receptor subtype. The strong functional union of this family is reflected ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Baxter G,Kennett G,Blaney F,Blackburn T

    更新日期:1995-03-01 00:00:00

  • Drugs of abuse: anatomy, pharmacology and function of reward pathways.

    abstract::Drugs of abuse are very powerful reinforcers, and even in conditions of limited access (where the organism is not dependent) these drugs will motivate high rates of operant responding. This presumed hedonic property and the drugs' neuropharmacological specificity provide a means of studying the neuropharmacology and n...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Koob GF

    更新日期:1992-05-01 00:00:00

  • Pharmacological Research as a Key Component in Mitigating the Opioid Overdose Crisis.

    abstract::The United States is experiencing an epidemic of opioid overdose deaths. Many of the recent fatalities are associated with illicitly manufactured fentanyl, which is being added to heroin and counterfeit pain pills. The crisis is further exacerbated by the emergence of an increasing number of novel synthetic opioids (N...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Baumann MH,Kopajtic TA,Madras BK

    更新日期:2018-12-01 00:00:00

  • Allosteric modulation of muscarinic acetylcholine receptors.

    abstract::Five subtypes of muscarinic acetylcholine receptors have been identified in mammalian tissues, but the selectivity of ligands that are active at these receptors is low. It is possible, however, that selective compounds may be developed by targeting their allosteric site(s). Important new insights into the mechanism of...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Tucek S,Proska J

    更新日期:1995-06-01 00:00:00

  • Stress, hormonal changes, alcohol, food constituents and drugs: factors that advance the incidence of tobacco smoke-related cancer?

    abstract::The genotoxicity of the most potent carcinogen in cigarette smoke [4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)] is dependent on the relationship between its activation by cytochrome P450 enzymes and its detoxification by carbonyl reduction to NNK alcohol (NNAL) followed by glucuronidation. Recently, '11 beta-...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Maser E

    更新日期:1997-08-01 00:00:00

  • Functional versus chemical diversity: is biodiversity important for drug discovery?

    abstract::Prospecting the full biodiversity of nature to find leads for new drugs is not necessary. Because finding leads is aimed at identifying biological activity, structure is of secondary importance. Furthermore, although natural chemical diversity might be unrivalled, functional diversity is bound to be considerably less....

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章


    authors: Tulp M,Bohlin L

    更新日期:2002-05-01 00:00:00

  • Small airways: an important but neglected target in the treatment of obstructive airway diseases.

    abstract::Changes in the structure and function of the small airways (<2mm diameter) are now recognized to play a major role in airflow limitation in both chronic obstructive pulmonary disease (COPD) and severe asthma. Increased thickness of the small airway wall causes lumenal narrowing, which can be further occluded by mucus ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Sturton G,Persson C,Barnes PJ

    更新日期:2008-07-01 00:00:00

  • Non-genomic and genomic effects of steroids on neural activity.

    abstract::Steroid hormones are recognized as producing their major long-term effects on cell structure and function via intracellular receptors acting on the expression of genes. There is now increasing evidence that steroids also affect the surface of cells and alter ion permeability, as well as release of neurohormones and ne...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: McEwen BS

    更新日期:1991-04-01 00:00:00

  • Neurobiology and treatment of Parkinson's disease.

    abstract::Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease and is an important cause of chronic disability. Numerous important advances have been made in our understanding of the aetiopathogenesis, pathology and clinical phenomenology of this disease, and these have underpi...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Schapira AH

    更新日期:2009-01-01 00:00:00

  • An Emerging Circuit Pharmacology of GABAA Receptors.

    abstract::In the past 20 years we have learned a great deal about GABAA receptor (GABAAR) subtypes, and which behaviors are regulated or which drug effects are mediated by each subtype. However, the question of where GABAARs involved in specific drug effects and behaviors are located in the brain remains largely unanswered. We ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Engin E,Benham RS,Rudolph U

    更新日期:2018-08-01 00:00:00

  • 007 (x2)-3-3: 14-3-3 Targeted Compounds as Double Agents.

    abstract::14-3-3 Proteins enact a range of cellular functions through protein-protein interactions (PPIs) with client proteins. Kaplan and colleagues recently demonstrated that a semisynthetic compound was able to selectively stabilize or disrupt specific interactions, depending on the binding partner. This finding presents an ...

    journal_title:Trends in pharmacological sciences

    pub_type: 评论,杂志文章


    authors: Gannon M,Yacoubian TA

    更新日期:2020-07-01 00:00:00

  • The Action Radius of Oxytocin Release in the Mammalian CNS: From Single Vesicles to Behavior.

    abstract::The hypothalamic neuropeptide oxytocin (OT) has attracted the attention both of the scientific community and a general audience because of its prosocial effects in mammals, and OT is now seen as a facilitator of mammalian species propagation. Furthermore, OT is a candidate for the treatment of social deficits in sever...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Chini B,Verhage M,Grinevich V

    更新日期:2017-11-01 00:00:00