Abstract:
:Heat shock proteins (HSPs) constitute a large family of proteins involved in protein folding and maturation whose expression is induced by heat shock or other stressors. The major groups are classified based on their molecular weights and include HSP27, HSP40, HSP60, HSP70, HSP90, and large HSPs. HSPs play a significant role in cellular proliferation, differentiation, and carcinogenesis. In this article we comprehensively review the roles of major HSPs in cancer biology and pharmacology. HSPs are thought to play significant roles in the molecular mechanisms leading to cancer development and metastasis. HSPs may also have potential clinical uses as biomarkers for cancer diagnosis, for assessing disease progression, or as therapeutic targets for cancer therapy.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Wu J,Liu T,Rios Z,Mei Q,Lin X,Cao Sdoi
10.1016/j.tips.2016.11.009subject
Has Abstractpub_date
2017-03-01 00:00:00pages
226-256issue
3eissn
0165-6147issn
1873-3735pii
S0165-6147(16)30167-5journal_volume
38pub_type
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journal_title:Trends in pharmacological sciences
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journal_title:Trends in pharmacological sciences
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journal_title:Trends in pharmacological sciences
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