Abstract：
:Attempts to develop neuroprotective treatments for neurodegenerative disorders have not yet been clinically successful. Axonal degeneration has been recognized as a predominant driver of disability and disease progression in central nervous system (CNS) diseases such as amyotrophic lateral sclerosis (ALS), multiple sclerosis, and Parkinson's disease, peripheral nervous system (PNS) disorders such as chemotherapy-induced, diabetic, and inherited neuropathies, and ocular disorders, such as glaucoma. In recent years, sterile alpha and TIR motif containing 1 (SARM1) has emerged as the first compelling axonal-specific target for therapeutic intervention. In this review, we discuss the role of axonal degeneration in neurodegenerative disorders, with a focus on SARM1 and the discovery of its intrinsic enzymatic function. Establishment of neurofilament light chain (NfL) as a reliable biomarker of axonal damage, and the availability of an ultrasensitive method for measuring NfL in plasma or serum, provide translational tools to make development of axonal protective, SARM1 inhibitors a viable approach to treat multiple neurodegenerative disorders.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Krauss R,Bosanac T,Devraj R,Engber T,Hughes ROdoi
10.1016/j.tips.2020.01.006subject
Has Abstractpub_date
2020-04-01 00:00:00pages
281-293issue
4eissn
0165-6147issn
1873-3735pii
S0165-6147(20)30006-7journal_volume
41pub_type
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