Non-genomic loss of PTEN function in cancer: not in my genes.

Abstract:

:Loss of function of the phosphatase and tensin homolog (PTEN) tumour suppressor contributes to the development of many cancers. However, in contrast to classical models of tumour suppression, partial loss of PTEN function appears to be frequently observed in the clinic. In addition, studies of both humans and mice with reductions in PTEN gene dosage indicate that even partial loss of PTEN function is sufficient to promote some cancer types, particularly in the breast. PTEN expression appears to be tightly controlled both transcriptionally and post-transcriptionally, with several recent studies implicating oncogenic microRNAs in PTEN suppression. The lipid phosphatase activity of PTEN can also be regulated post-translationally via inhibitory phosphorylation, ubiquitination or oxidation. Here we discuss these multiple mechanisms of PTEN regulation. We also put into context recent proposals that changes in this regulation can drive tumour development and address the accompanying evidence for their clinical significance.

journal_name

Trends Pharmacol Sci

authors

Leslie NR,Foti M

doi

10.1016/j.tips.2010.12.005

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

131-40

issue

3

eissn

0165-6147

issn

1873-3735

pii

S0165-6147(10)00217-8

journal_volume

32

pub_type

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