Abstract：
:In the discipline of pharmacology, drugs (ligands) are used as tools to elucidate the processes of biological systems. Because of this, pharmacologists strive to delineate all characteristics of drugs. Decades of research have resulted in the proposal that ligands possess two properties that are intrinsic to the ligand and are invariant of the system in which their effects are investigated. These properties are affinity (the capacity of a drug to bind to a receptor) and intrinsic efficacy (the capacity of a drug to activate or inactivate a receptor). Although affinity is a relatively easy parameter to measure with a variety of techniques, ways of quantifying intrinsic efficacy have remained elusive ever since its inception. Furthermore, recent evidence suggests that intrinsic efficacy might not be a single, ligand-dependent parameter but that agonists might have multiple intrinsic efficacies. William Clarke and Richard Bond discuss several reasons why the claim that intrinsic efficacy is a ligand-dependent parameter should be questioned, and the possible impact of these findings.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Clarke WP,Bond RAdoi
10.1016/s0165-6147(97)01138-3subject
Has Abstractpub_date
1998-07-01 00:00:00pages
270-6issue
7eissn
0165-6147issn
1873-3735pii
S0165-6147(97)01138-3journal_volume
19pub_type
杂志文章,评审abstract：:Neonatal Fc receptors (FcRns) recycle IgGs by preventing their lysosome degradation. As this process also enhances half-life of pathogenic auto-IgG, inspired from the mechanisms of intravenous immunoglobulin, several inhibitors of IgG-FcRn interface have been conceived for treating autoimmune diseases. Among them, the...
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journal_title：Trends in pharmacological sciences
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journal_title：Trends in pharmacological sciences
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更新日期：2017-08-01 00:00:00
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journal_title：Trends in pharmacological sciences
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