Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines.

Abstract:

:NMDA and non-NMDA (AMPA/kainate) antagonists have potential in the treatment of a diverse group of neurological disorders associated with excessive activation of excitatory amino acid receptors. Here Michael Rogawski reviews recent progress in the development of therapeutically useful NMDA receptor channel blockers and a new class of selective AMPA/kainate receptor antagonists, the 2,3-benzodiazepines. Research on these novel noncompetitive excitatory amino acid antagonists has opened promising new avenues for the development of drugs to treat epilepsy, ischaemia, neurodegeneration and Parkinson's disease.

journal_name

Trends Pharmacol Sci

authors

Rogawski MA

doi

10.1016/0165-6147(93)90005-5

subject

Has Abstract

pub_date

1993-09-01 00:00:00

pages

325-31

issue

9

eissn

0165-6147

issn

1873-3735

pii

0165-6147(93)90005-5

journal_volume

14

pub_type

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