Therapeutic Targeting of Siglecs using Antibody- and Glycan-Based Approaches.

Abstract:

:The sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of immunomodulatory receptors whose functions are regulated by their glycan ligands. Siglecs are attractive therapeutic targets because of their cell type-specific expression pattern, endocytic properties, high expression on certain lymphomas/leukemias, and ability to modulate receptor signaling. Siglec-targeting approaches with therapeutic potential encompass antibody- and glycan-based strategies. Several antibody-based therapies are in clinical trials and continue to be developed for the treatment of lymphoma/leukemia and autoimmune disease, while the therapeutic potential of glycan-based strategies for cargo delivery and immunomodulation is a promising new approach. Here we review these strategies with special emphasis on emerging approaches and disease areas that may benefit from targeting the Siglec family.

journal_name

Trends Pharmacol Sci

authors

Angata T,Nycholat CM,Macauley MS

doi

10.1016/j.tips.2015.06.008

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

645-660

issue

10

eissn

0165-6147

issn

1873-3735

pii

S0165-6147(15)00137-6

journal_volume

36

pub_type

杂志文章,评审
  • Using genotyping to predict responses to anti-hypertensive treatment.

    abstract::Hypertension is prevalent and affects approximately 1 in every 4 adults in the Western world. Although many drugs are effective in treating hypertension, an individual's response to treatment is unpredictable. Pharmacogenetics holds the promise of becoming a tool to predict this response but obstacles and shortcomings...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/j.tips.2005.07.008

    authors: Kurland L,Lind L,Melhus H

    更新日期:2005-09-01 00:00:00

  • Research applications and implications of adenosine in diseased airways.

    abstract::Adenosine, when given by inhalation, initiates the narrowing of airways in subjects with asthma or chronic obstructive pulmonary disease (COPD). The underlying mechanism of this narrowing appears to involve the stimulation of specific mast cell surface adenosine receptors with the subsequent release of mediators and c...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/S0165-6147(03)00193-7

    authors: Spicuzza L,Bonfiglio C,Polosa R

    更新日期:2003-08-01 00:00:00

  • GPCRs in NLRP3 Inflammasome Activation, Regulation, and Therapeutics.

    abstract::The NLRP3 inflammasome is an intracellular multimeric protein complex which plays an important role in the pathogenesis of various human inflammatory diseases, such as diabetes, Alzheimer's disease and atherosclerosis. Recently, various G protein-coupled receptors (GPCRs) have been reported to be involved in the activ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2018.07.002

    authors: Tang T,Gong T,Jiang W,Zhou R

    更新日期:2018-09-01 00:00:00

  • Off-target effects associated with long dsRNAs in Drosophila RNAi screens.

    abstract::Evidence of off-target effects (OTEs) associated with small interfering (si)RNAs (19-29bp) in mammalian cells has existed for several years. Two recent articles demonstrate that short sequences within long double-stranded (ds)RNAs frequently cause undesirable OTEs in cultured Drosophila cells. These results reveal the...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/j.tips.2007.02.009

    authors: Moffat J,Reiling JH,Sabatini DM

    更新日期:2007-04-01 00:00:00

  • Analysis of competitive agonist-antagonist interactions by nonlinear regression.

    abstract::The rigorous estimation of a dissociation constant (Kb) for antagonists in functional assays has been sought by pharmacologists using a variety of techniques ever since the regression method of Arunlakshana and Schild in 1959. Here, Michael Lew and James Angus describe a simplified global regression method with improv...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-6147(00)89066-5

    authors: Lew MJ,Angus JA

    更新日期:1995-10-01 00:00:00

  • Receptor-activated Ca2+ influx: how many mechanisms for how many channels?

    abstract::Receptors that are coupled to the production of inositol (1,4,5)-trisphosphate cause an increase in cytosolic free Ca2+ concentration as a consequence of both Ca2+ mobilization from intracellular stores and Ca2+ influx through the plasma membrane. Although this latter phenomenon appears attributable to the activation ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/0165-6147(94)90282-8

    authors: Fasolato C,Innocenti B,Pozzan T

    更新日期:1994-03-01 00:00:00

  • Regulation of vascular reactivity by established and emerging GPCRs.

    abstract::The vascular system is rich in G-protein-coupled receptors (GPCRs), particularly Class 1 GPCRs, which are activated by an eclectic range of chemical entities including peptides. These chemical messengers can function in blood vessels as directly acting vasoconstrictors, directly acting vasodilators or indirectly actin...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/j.tips.2005.07.007

    authors: Maguire JJ,Davenport AP

    更新日期:2005-09-01 00:00:00

  • Drugging unconventional targets: insights from Huntington's disease.

    abstract::Classical targeted drug discovery is based on targeting druggable targets, typically kinases and receptors of which the function can be agonized or antagonized. This strategy meets difficulties in cases such as Huntington's disease (HD) and similar neurodegenerative disorders, where the pathological function of the pr...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2013.12.001

    authors: Yu S,Liang Y,Palacino J,Difiglia M,Lu B

    更新日期:2014-02-01 00:00:00

  • Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling.

    abstract::Recent advances in schizophrenia (SZ) research indicate that the telencephalic gamma-aminobutyric acid (GABA)ergic neurotransmission deficit associated with this psychiatric disorder probably is mediated by the hypermethylation of the glutamic acid decarboxylase 67 (GAD(67)), reelin and other GABAergic promoters. A ph...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/j.tips.2008.10.010

    authors: Guidotti A,Dong E,Kundakovic M,Satta R,Grayson DR,Costa E

    更新日期:2009-02-01 00:00:00

  • Nematode genome sequence dramatically extends the nuclear receptor superfamily.

    abstract::Nuclear receptors represent a large class of ligand-activated transcriptional regulators; about 70 members of this protein family have been cloned from mammalian or insect species. Thus, it came as a great surprise when the recent completion of the Caenorhabditis elegans genome revealed at least 228 genes for nuclear ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-6147(99)01417-0

    authors: Enmark E,Gustafsson JA

    更新日期:2000-03-01 00:00:00

  • New insights into activation of the steroid hormone receptor superfamily.

    abstract::For many years the prevailing view of how steroid hormone receptors exert their effects on gene transcription has been that these intracellular receptor proteins, upon association with their specific cognate ligands, undergo a transformation to a state where they are capable of interacting with chromatin and regulatin...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/0165-6147(92)90099-r

    authors: Power RF,Conneely OM,O'Malley BW

    更新日期:1992-08-01 00:00:00

  • Novel Targeted Therapies for Inflammatory Bowel Disease.

    abstract::Our growing understanding of the immunopathogenesis of inflammatory bowel disease (IBD) has opened new avenues for developing targeted therapies. These advances in treatment options targeting different mechanisms of action offer new hope for personalized management. In this review we highlight emerging novel and easil...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2016.10.014

    authors: Coskun M,Vermeire S,Nielsen OH

    更新日期:2017-02-01 00:00:00

  • New pharmacological strategies to fight enveloped viruses.

    abstract::Enveloped viruses pose an important health threat because most of the persistent and many emerging viruses are enveloped. In particular, newly emerging viruses create a need to develop broad-spectrum antivirals, which usually are obtained by targeting host cell factors. Persistent viruses have developed efficient stra...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2014.06.004

    authors: Wisskirchen K,Lucifora J,Michler T,Protzer U

    更新日期:2014-09-01 00:00:00

  • Recent findings on the mode of action of laxatives: the role of platelet activating factor and nitric oxide.

    abstract::Platelet activating factor (PAF) is a phospholipid mediator of inflammation and stimulates anion secretion in animals and in isolated preparations of human colon. Nitric oxide (NO), synthesized from the amino acid L-arginine, is an important enteric inhibitory neurotransmitter. In addition, NO-donating compounds stimu...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-6147(98)01249-8

    authors: Izzo AA,Gaginella TS,Mascolo N,Capasso F

    更新日期:1998-10-01 00:00:00

  • Glutamate receptor channel signatures.

    abstract::Genes encoding glutamate receptor channel subunits were identified in genomes from Drosophila melanogaster and Caenorhabditis elegans by homology search with amino acid sequences that participate in the conserved channel pore. The predicted sequences of the putative glutamate receptor subunits revealed a distinct chan...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/s0165-6147(00)01588-1

    authors: Sprengel R,Aronoff R,Völkner M,Schmitt B,Mosbach R,Kuner T

    更新日期:2001-01-01 00:00:00

  • Hormone and growth factor receptor-mediated regulation of phospholipase C activity.

    abstract::The broad importance of receptor-activated phosphoinositide hydrolysis in the physiological action of hormones, neurotransmitters and growth factors has sparked interest in the study of transmembrane signalling events responsible for activation of phospholipase C. As with receptors involved in regulation of adenylyl c...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/0165-6147(89)90008-4

    authors: Boyer JL,Hepler JR,Harden TK

    更新日期:1989-09-01 00:00:00

  • The developing use of heterozygous mutant mouse models in brain monoamine transporter research.

    abstract::5-Hydroxytryptamine (5-HT), dopamine and norepinephrine are important monoamine neurotransmitters implicated in multiple brain mechanisms and regulated by high-affinity transmembrane monoamine transporters. Although knockout mice lacking 5-HT, dopamine or norepinephrine transporters are widely used to assess brain mon...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2007.01.002

    authors: Kalueff AV,Ren-Patterson RF,Murphy DL

    更新日期:2007-03-01 00:00:00

  • Targeting SREBPs for treatment of the metabolic syndrome.

    abstract::Over the past few decades, mortality resulting from cardiovascular disease (CVD) steadily decreased in western countries; however, in recent years, the decline has become offset by the increase in obesity. Obesity is strongly associated with the metabolic syndrome and its atherogenic dyslipidemia resulting from insuli...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2015.04.010

    authors: Soyal SM,Nofziger C,Dossena S,Paulmichl M,Patsch W

    更新日期:2015-06-01 00:00:00

  • Methylphenidate and cocaine: the same effects on gene regulation?

    abstract::Methylphenidate (Ritalin), a psychostimulant used in the treatment of Attention-Deficit Hyperactivity Disorder, has pharmacological effects similar to cocaine and amphetamine. Clinical use of methylphenidate, as well as diversion and abuse, have significantly increased during the past 10-15 years, heightening concerns...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2007.10.004

    authors: Yano M,Steiner H

    更新日期:2007-11-01 00:00:00

  • The missing link: chemokine receptors and tissue matrix breakdown in COPD.

    abstract::Chronic obstructive pulmonary disease (COPD) is a pulmonary inflammatory disease that is caused by cigarette smoke. The main characteristic of COPD is the continued inflammation caused by the sustained influx of macrophages and neutrophils into the lung. Recent studies have shed light on how these cells are attracted ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/j.tips.2006.09.003

    authors: Smit JJ,Lukacs NW

    更新日期:2006-11-01 00:00:00

  • NAADP: an atypical Ca2+-release messenger?

    abstract::Recently, nicotinic acid adenine dinucleotide phosphate (NAADP) has been shown, using different techniques, to mobilize intracellular Ca2+ stores in invertebrate, lower vertebrate, plant and mammalian cells. This endogenous molecule might play an atypical role in Ca2+ signalling by coordinating the responses of other ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-6147(00)01990-8

    authors: Genazzani AA,Billington RA

    更新日期:2002-04-01 00:00:00

  • Heat Shock Proteins and Cancer.

    abstract::Heat shock proteins (HSPs) constitute a large family of proteins involved in protein folding and maturation whose expression is induced by heat shock or other stressors. The major groups are classified based on their molecular weights and include HSP27, HSP40, HSP60, HSP70, HSP90, and large HSPs. HSPs play a significa...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2016.11.009

    authors: Wu J,Liu T,Rios Z,Mei Q,Lin X,Cao S

    更新日期:2017-03-01 00:00:00

  • Preclinical models of antipsychotic drug-induced metabolic side effects.

    abstract::Antipsychotic drugs (APDs), and the 'atypical' APDs in particular, are commonly associated with metabolic side effects in humans. These include glucose dysregulation, insulin resistance, hyperlipidemia, weight gain and hypertension, which put patients at increased risk of cardiometabolic disorders. The underlying biol...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2010.07.002

    authors: Boyda HN,Tse L,Procyshyn RM,Honer WG,Barr AM

    更新日期:2010-10-01 00:00:00

  • A Coordinated Attack: Rett Syndrome Therapeutic Development.

    abstract::Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the Methyl CpG binding protein 2 (MeCP2) gene. This Science & Society article focuses on pharmacological strategies that attack RTT treatment from multiple angles, including drug repurposing and de novo discovery efforts, and discusses the imp...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2019.02.007

    authors: Gogliotti RG,Niswender CM

    更新日期:2019-04-01 00:00:00

  • Nicotine addiction: the possible role of functional upregulation.

    abstract::Upregulation of binding to nicotinic acetylcholine receptors (nAChRs) is observed in the brains of both smokers and animals chronically exposed to nicotine, although whether this in vivo change is accompanied by an increase in receptor function is unknown. In vitro recordings indicate that alpha4beta2- and alpha7-subt...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/S0165-6147(00)01979-9

    authors: Buisson B,Bertrand D

    更新日期:2002-03-01 00:00:00

  • Hans Horst Meyer and the lipoid theory of narcosis.

    abstract::This year marks the 90th anniversary of the publication of Hans Horst Meyer's classic paper in which he proposed that the ability of a substance to produce narcosis or anesthesia is governed by its partition coefficient. In this article, Robert Lipnick describes the experiments carried out by Meyer and his colleagues ...

    journal_title:Trends in pharmacological sciences

    pub_type: 传,历史文章,杂志文章

    doi:10.1016/0165-6147(89)90025-4

    authors: Lipnick RL

    更新日期:1989-07-01 00:00:00

  • Rho kinase: a target for treating urinary bladder dysfunction?

    abstract::Urinary incontinence and other urinary storage symptoms are frequent in the general population but available treatments have limited efficacy and tolerability. Rho kinase (ROCK) has a central role in the regulation of smooth muscle contraction, including that of the urinary bladder. Recent experimental evidence indica...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2006.07.002

    authors: Peters SL,Schmidt M,Michel MC

    更新日期:2006-09-01 00:00:00

  • Higher-order organization and regulation of adenylyl cyclases.

    abstract::There is increasing awareness of the compartmentalization of cAMP signalling--the means by which cAMP levels change in discrete domains of the cell with discrete local consequences. Current developments in understanding the organization of adenylyl cyclases in the plasma membrane are illuminating how the earliest part...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2006.06.002

    authors: Cooper DM,Crossthwaite AJ

    更新日期:2006-08-01 00:00:00

  • The benzodiazepine binding site of GABAA receptors.

    abstract::The GABAA receptor belongs, along with the nicotinic acetylcholine receptor, the glycine receptor and the 5-HT3 receptor, to a family of homologous transmitter-gated ion channels mediating fast synaptic transmission. Many classes of drug interact with the GABAA receptor, which is the major inhibitory ion channel in th...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-6147(97)01118-8

    authors: Sigel E,Buhr A

    更新日期:1997-11-01 00:00:00

  • Do cannabinoids have a therapeutic role in transplantation?

    abstract::Cannabinoids have emerged as powerful drug candidates for the treatment of inflammatory and autoimmune diseases due to their immunosuppressive properties. Significant clinical and experimental data on the use of cannabinoids as anti-inflammatory agents exist in many autoimmune disease settings, but virtually no studie...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tips.2010.05.006

    authors: Nagarkatti M,Rieder SA,Hegde VL,Kanada S,Nagarkatti P

    更新日期:2010-08-01 00:00:00