Therapeutic Targeting of Siglecs using Antibody- and Glycan-Based Approaches.

Abstract:

:The sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of immunomodulatory receptors whose functions are regulated by their glycan ligands. Siglecs are attractive therapeutic targets because of their cell type-specific expression pattern, endocytic properties, high expression on certain lymphomas/leukemias, and ability to modulate receptor signaling. Siglec-targeting approaches with therapeutic potential encompass antibody- and glycan-based strategies. Several antibody-based therapies are in clinical trials and continue to be developed for the treatment of lymphoma/leukemia and autoimmune disease, while the therapeutic potential of glycan-based strategies for cargo delivery and immunomodulation is a promising new approach. Here we review these strategies with special emphasis on emerging approaches and disease areas that may benefit from targeting the Siglec family.

journal_name

Trends Pharmacol Sci

authors

Angata T,Nycholat CM,Macauley MS

doi

10.1016/j.tips.2015.06.008

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

645-660

issue

10

eissn

0165-6147

issn

1873-3735

pii

S0165-6147(15)00137-6

journal_volume

36

pub_type

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