Abstract：
:The sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of immunomodulatory receptors whose functions are regulated by their glycan ligands. Siglecs are attractive therapeutic targets because of their cell type-specific expression pattern, endocytic properties, high expression on certain lymphomas/leukemias, and ability to modulate receptor signaling. Siglec-targeting approaches with therapeutic potential encompass antibody- and glycan-based strategies. Several antibody-based therapies are in clinical trials and continue to be developed for the treatment of lymphoma/leukemia and autoimmune disease, while the therapeutic potential of glycan-based strategies for cargo delivery and immunomodulation is a promising new approach. Here we review these strategies with special emphasis on emerging approaches and disease areas that may benefit from targeting the Siglec family.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Angata T,Nycholat CM,Macauley MSdoi
10.1016/j.tips.2015.06.008subject
Has Abstractpub_date
2015-10-01 00:00:00pages
645-660issue
10eissn
0165-6147issn
1873-3735pii
S0165-6147(15)00137-6journal_volume
36pub_type
杂志文章,评审abstract：:Exposure of cells to agonists of receptors linked to G proteins can result in downregulation of cellular levels or redistribution of G proteins from membranes to the cytosol. Agonist-induced reductions in G protein levels have been observed for members of each of the Gs, Gi and Gq families of G proteins, are likely to...
journal_title：Trends in pharmacological sciences
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journal_title：Trends in pharmacological sciences
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更新日期：2012-07-01 00:00:00
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