Abstract：
:Oxycodone is a semisynthetic opioid analgesic that is increasingly used for the treatment of acute, cancer, and chronic non-malignant pain. Oxycodone was synthesized in 1917 but its pharmacological properties were not thoroughly studied until recently. Oxycodone is a fairly selective μ-opioid receptor agonist, but there is a striking discrepancy between the relatively low binding potential and G protein activation by oxycodone and its analgesic efficacy. It has been claimed that this is because of active metabolites and enhanced passage to the central nervous system by active transport. We critically review studies on the basic pharmacology of oxycodone and on its pharmacokinetics and pharmacodynamics in humans. In particular, the role of pharmacogenomics and population pharmacokinetics in understanding the properties of oxycodone is discussed in detail. We compare oxycodone with morphine, the standard opioid in clinical use.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Olkkola KT,Kontinen VK,Saari TI,Kalso EAdoi
10.1016/j.tips.2013.02.001subject
Has Abstractpub_date
2013-04-01 00:00:00pages
206-14issue
4eissn
0165-6147issn
1873-3735pii
S0165-6147(13)00025-4journal_volume
34pub_type
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