Abstract:
:Alanine-glyoxylate aminotransferase 2 (AGXT2) is a multifunctional mitochondrial aminotransferase that was first identified in 1978. The physiological importance of AGXT2 was largely overlooked for three decades because AGXT2 is less active in glyoxylate metabolism than AGXT1, the enzyme that is deficient in primary hyperoxaluria type I. Recently, several novel functions of AGXT2 have been 'rediscovered' in the setting of modern genomic and metabolomic studies. It is now apparent that AGXT2 has multiple substrates and products and that altered AGXT2 activity may contribute to the pathogenesis of cardiovascular, renal, neurological, and hematological diseases. This article reviews the biochemical properties and physiological functions of AGXT2, its unique role at the intersection of key mitochondrial pathways, and its potential as a drug target.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Rodionov RN,Jarzebska N,Weiss N,Lentz SRdoi
10.1016/j.tips.2014.09.005subject
Has Abstractpub_date
2014-11-01 00:00:00pages
575-82issue
11eissn
0165-6147issn
1873-3735pii
S0165-6147(14)00150-3journal_volume
35pub_type
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