Control of transmitter release from the motor nerve by presynaptic nicotinic and muscarinic autoreceptors.

Abstract:

:Until recently, release studies have failed to indicate the existence of autoreceptors on motor nerves. Ignaz Wessler now reports on a refinement of the technique - the measurement of newly synthesized [3H]acetylcholine released from the phrenic nerve - which provides clear evidence in support of release-modulating autoreceptors. Presynaptic nicotinic receptors mediate a positive feedback mechanism, can rapidly be desensitized and appear to differ in their pharmacological profile from the postsynaptic receptors. In addition, inhibitory and facilitatory muscarinic receptors appear to be involved in the presynaptic control of transmitter release from the phrenic nerve.

journal_name

Trends Pharmacol Sci

authors

Wessler I

doi

10.1016/0165-6147(89)90208-3

subject

Has Abstract

pub_date

1989-03-01 00:00:00

pages

110-4

issue

3

eissn

0165-6147

issn

1873-3735

pii

0165-6147(89)90208-3

journal_volume

10

pub_type

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