Abstract:
:Until recently, release studies have failed to indicate the existence of autoreceptors on motor nerves. Ignaz Wessler now reports on a refinement of the technique - the measurement of newly synthesized [3H]acetylcholine released from the phrenic nerve - which provides clear evidence in support of release-modulating autoreceptors. Presynaptic nicotinic receptors mediate a positive feedback mechanism, can rapidly be desensitized and appear to differ in their pharmacological profile from the postsynaptic receptors. In addition, inhibitory and facilitatory muscarinic receptors appear to be involved in the presynaptic control of transmitter release from the phrenic nerve.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Wessler Idoi
10.1016/0165-6147(89)90208-3subject
Has Abstractpub_date
1989-03-01 00:00:00pages
110-4issue
3eissn
0165-6147issn
1873-3735pii
0165-6147(89)90208-3journal_volume
10pub_type
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