Abstract：
:During the past decade a great number of genes encoding high- and low-voltage-dependent Ca(2+) channels and their accessory subunits have been cloned. Studies of Ca(2+) channel structure-function relationships and channel regulation using cDNA expression in heterologous expression systems have revealed intricate details of subunit interaction, regulation of channels by protein kinase A (PKA) and protein kinase C (PKC), drug binding sites, mechanisms of drug action, the ion conduction pathway and other aspects of channel function. In recent years, however, we have arrived at the brink of an entirely new strategy to study Ca(2+) channels by overexpressing or knocking out genes encoding these channels in transgenic mice. In this article, various models of gene knockout or gene overexpression will be discussed. This new approach will reveal many secrets regarding Ca(2+) channel regulation and the control of Ca(2+)-dependent cellular processes.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Muth JN,Varadi G,Schwartz Adoi
10.1016/s0165-6147(00)01797-1subject
Has Abstractpub_date
2001-10-01 00:00:00pages
526-32issue
10eissn
0165-6147issn
1873-3735pii
S0165-6147(00)01797-1journal_volume
22pub_type
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