Abstract:
:14-3-3 Proteins enact a range of cellular functions through protein-protein interactions (PPIs) with client proteins. Kaplan and colleagues recently demonstrated that a semisynthetic compound was able to selectively stabilize or disrupt specific interactions, depending on the binding partner. This finding presents an exciting possibility of designing other 14-3-3 compounds to regulate critical 14-3-3 interactions.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Gannon M,Yacoubian TAdoi
10.1016/j.tips.2020.05.001subject
Has Abstractpub_date
2020-07-01 00:00:00pages
431-433issue
7eissn
0165-6147issn
1873-3735pii
S0165-6147(20)30108-5journal_volume
41pub_type
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