007 (x2)-3-3: 14-3-3 Targeted Compounds as Double Agents.


:14-3-3 Proteins enact a range of cellular functions through protein-protein interactions (PPIs) with client proteins. Kaplan and colleagues recently demonstrated that a semisynthetic compound was able to selectively stabilize or disrupt specific interactions, depending on the binding partner. This finding presents an exciting possibility of designing other 14-3-3 compounds to regulate critical 14-3-3 interactions.


Trends Pharmacol Sci


Gannon M,Yacoubian TA




Has Abstract


2020-07-01 00:00:00














  • Targeting inflammation and wound healing by opioids.

    abstract::Opioid receptors are expressed on peripheral sensory nerve endings, cutaneous cells, and immune cells; and local application of opioids is used for the treatment of inflammatory pain in arthritis, burns, skin grafts, and chronic wounds. However, peripherally active opioids can also directly modulate the inflammatory p...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章


    authors: Stein C,Küchler S

    更新日期:2013-06-01 00:00:00

  • Receptor-activated Ca2+ influx: how many mechanisms for how many channels?

    abstract::Receptors that are coupled to the production of inositol (1,4,5)-trisphosphate cause an increase in cytosolic free Ca2+ concentration as a consequence of both Ca2+ mobilization from intracellular stores and Ca2+ influx through the plasma membrane. Although this latter phenomenon appears attributable to the activation ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Fasolato C,Innocenti B,Pozzan T

    更新日期:1994-03-01 00:00:00

  • Phospholipase A2 enzymes: regulation and inhibition.

    abstract::The phospholipase A2 enzymes are important components of the cellular machinery that responds to inflammatory stimuli and maintains cell homeostasis by membrane remodelling. Their role as the rate-limiting step in the production of pro-inflammatory lipid mediators makes these enzymes an important therapeutic target fo...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Glaser KB,Mobilio D,Chang JY,Senko N

    更新日期:1993-03-01 00:00:00

  • Novel interactions between K+ channels and scorpion toxins.

    abstract::K(+) channels are macromolecules embedded in biological membranes, where they play a key role in cellular excitability and signal transduction pathways. Knowledge of their structure should help improve our understanding of their function and lead to the design of therapeutic compounds. Most pharmacological and structu...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Rodríguez de la Vega RC,Merino E,Becerril B,Possani LD

    更新日期:2003-05-01 00:00:00

  • Modulation of transmitter release via presynaptic cannabinoid receptors.

    abstract::Cannabis (marijuana) is not only a frequently abused drug but also has the potential for the development of useful agents for the treatment of emesis, anorexia and multiple sclerosis. In this article, the effects of modulation of transmitter release by cannabinoids in both the CNS and the PNS of various species, inclu...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Schlicker E,Kathmann M

    更新日期:2001-11-01 00:00:00

  • Neuropharmacological Insight from Allosteric Modulation of mGlu Receptors.

    abstract::The metabotropic glutamate (mGlu) receptors are a family of G-protein-coupled receptors (GPCRs) that regulate cell physiology throughout the nervous system. The potential of mGlu receptors as therapeutic targets has been bolstered by current research that has provided insight into the diverse modes of mGlu activation ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Stansley BJ,Conn PJ

    更新日期:2019-04-01 00:00:00

  • Ischaemic preconditioning of the vasculature: an overlooked phenomenon for protecting the heart?

    abstract::Exposing the heart to brief episodes of ischaemia protects the myocardium and vascular endothelial cells against functional damage and cell death caused by subsequent prolonged ischaemia. Elucidation of the mechanisms that are involved in this phenomenon known as 'ischaemic preconditioning' and identification of drugs...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Rubino A,Yellon DM

    更新日期:2000-06-01 00:00:00

  • Cancer Drug Development Using Drosophila as an in vivo Tool: From Bedside to Bench and Back.

    abstract::The fruit fly Drosophila melanogaster has been used for modeling cancer and as an in vivo tool for the validation and/or development of cancer therapeutics. The impetus for the use of Drosophila in cancer research stems from the high conservation of its signaling pathways, lower genetic redundancy, short life cycle, g...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Yadav AK,Srikrishna S,Gupta SC

    更新日期:2016-09-01 00:00:00

  • Siglecs as targets for therapy in immune-cell-mediated disease.

    abstract::The sialic-acid-binding immunoglobulin-like lectins (siglecs) comprise a family of receptors that are differentially expressed on leukocytes and other immune cells. The restricted expression of several siglecs to one or a few cell types makes them attractive targets for cell-directed therapies. The anti-CD33 (also kno...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: O'Reilly MK,Paulson JC

    更新日期:2009-05-01 00:00:00

  • Do cannabinoids have a therapeutic role in transplantation?

    abstract::Cannabinoids have emerged as powerful drug candidates for the treatment of inflammatory and autoimmune diseases due to their immunosuppressive properties. Significant clinical and experimental data on the use of cannabinoids as anti-inflammatory agents exist in many autoimmune disease settings, but virtually no studie...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Nagarkatti M,Rieder SA,Hegde VL,Kanada S,Nagarkatti P

    更新日期:2010-08-01 00:00:00

  • Elucidating cell signaling mechanisms using antisense technology.

    abstract::Many diseases result from defects in cell signaling. Achieving an in-depth understanding of the complex mechanisms by which cells transduce extracellular signals into cellular responses in both normal and diseased systems is a crucial step in the discovery of more effective drugs to treat human diseases. Traditional a...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Koller E,Gaarde WA,Monia BP

    更新日期:2000-04-01 00:00:00

  • An emerging role for PtdIns(4,5)P2-mediated signalling in human disease.

    abstract::Although an established regulator of many cellular functions, the phosphoinositide phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P2) appears to have evaded the attention of drug-discovery companies. An increasing number of reports have identified potential links between PtdIns(4,5)P2-mediated signalling pathways...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Halstead JR,Jalink K,Divecha N

    更新日期:2005-12-01 00:00:00

  • Beware of docking!

    abstract::Docking is now routine in virtual screening or lead optimization for drug screening and design. The number of papers related to docking has dramatically increased over the past decade. However, there are many issues to consider when undertaking a docking study. Frequent problems or issues arise, such as the wrong bind...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Chen YC

    更新日期:2015-02-01 00:00:00

  • Acquired somatic mutations in the molecular pathogenesis of COPD.

    abstract::Chronic obstructive pulmonary disease (COPD) is caused mostly by cigarette smoking but its specific molecular mechanisms are obscure. Current theories suggest that the inflammation and oxidative stress induced by smoking lead to proteolytic imbalance and progressive lung structural derangement, with disease susceptibi...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Anderson GP,Bozinovski S

    更新日期:2003-02-01 00:00:00

  • GPCRs in NLRP3 Inflammasome Activation, Regulation, and Therapeutics.

    abstract::The NLRP3 inflammasome is an intracellular multimeric protein complex which plays an important role in the pathogenesis of various human inflammatory diseases, such as diabetes, Alzheimer's disease and atherosclerosis. Recently, various G protein-coupled receptors (GPCRs) have been reported to be involved in the activ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Tang T,Gong T,Jiang W,Zhou R

    更新日期:2018-09-01 00:00:00

  • The darker side of Ca2+ signaling by neuronal Ca2+-sensor proteins: from Alzheimer's disease to cancer.

    abstract::Neuronal Ca2+-sensor (NCS) proteins constitute a subfamily of closely related EF-hand Ca2+-binding proteins that are expressed mainly in neurons or retinal photoreceptor cells. A variety of different neuronal functions have been attributed to these proteins. However, important new discoveries indicate that these prote...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Braunewell KH

    更新日期:2005-07-01 00:00:00

  • Functional versus chemical diversity: is biodiversity important for drug discovery?

    abstract::Prospecting the full biodiversity of nature to find leads for new drugs is not necessary. Because finding leads is aimed at identifying biological activity, structure is of secondary importance. Furthermore, although natural chemical diversity might be unrivalled, functional diversity is bound to be considerably less....

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章


    authors: Tulp M,Bohlin L

    更新日期:2002-05-01 00:00:00

  • Newly discovered tachykinins raise new questions about their peripheral roles and the tachykinin nomenclature.

    abstract::The tachykinin family has recently been extended by the discovery of a third tachykinin gene encoding previously unknown mammalian tachykinins (hemokinin 1, endokinin A and endokinin B) that have a widespread peripheral distribution and a tachykinin NK(1) receptor selectivity. This and the identification of other tach...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Patacchini R,Lecci A,Holzer P,Maggi CA

    更新日期:2004-01-01 00:00:00

  • Nicotine addiction: the possible role of functional upregulation.

    abstract::Upregulation of binding to nicotinic acetylcholine receptors (nAChRs) is observed in the brains of both smokers and animals chronically exposed to nicotine, although whether this in vivo change is accompanied by an increase in receptor function is unknown. In vitro recordings indicate that alpha4beta2- and alpha7-subt...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Buisson B,Bertrand D

    更新日期:2002-03-01 00:00:00

  • Endothelium-dependent hyperpolarization: a role in the control of vascular tone.

    abstract::Endothelial-dependent relaxation of vascular smooth muscle cells evoked by a number of agonists, including cholinomimetics and substance P, is often accompanied by an increase (repolarization and/or hyperpolarization) in the membrane potential. This change in membrane potential appears predominantly to reflect the act...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Garland CJ,Plane F,Kemp BK,Cocks TM

    更新日期:1995-01-01 00:00:00

  • The sigma-1 receptor chaperone as an inter-organelle signaling modulator.

    abstract::Inter-organelle signaling plays important roles in many physiological functions. Endoplasmic reticulum (ER)-mitochondrion signaling affects intramitochondrial calcium (Ca(2+)) homeostasis and cellular bioenergetics. ER-nucleus signaling attenuates ER stress. ER-plasma membrane signaling regulates cytosolic Ca(2+) home...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章


    authors: Su TP,Hayashi T,Maurice T,Buch S,Ruoho AE

    更新日期:2010-12-01 00:00:00

  • 5-HT2 receptor subtypes: a family re-united?

    abstract::The current classification for 5-HT2 receptors accommodates three subtypes. In addition to the originally defined 5-HT2 receptor, sanctuary is now provided for the structurally related 5-HT1c receptor (now 5-HT2c) and at least one atypical 5-HT receptor subtype. The strong functional union of this family is reflected ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Baxter G,Kennett G,Blaney F,Blackburn T

    更新日期:1995-03-01 00:00:00

  • Non-genomic loss of PTEN function in cancer: not in my genes.

    abstract::Loss of function of the phosphatase and tensin homolog (PTEN) tumour suppressor contributes to the development of many cancers. However, in contrast to classical models of tumour suppression, partial loss of PTEN function appears to be frequently observed in the clinic. In addition, studies of both humans and mice wit...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Leslie NR,Foti M

    更新日期:2011-03-01 00:00:00

  • Suppressing production of reactive oxygen species (ROS) for influenza A virus therapy.

    abstract::Influenza A viral infections claim millions of lives worldwide and continue to impose a major burden on healthcare systems. Current pharmacological strategies to control influenza A virus-induced lung disease are problematic owing to antiviral resistance and the requirement for strain-specific vaccination. The product...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Vlahos R,Stambas J,Selemidis S

    更新日期:2012-01-01 00:00:00

  • Toxicology of simple and complex mixtures.

    abstract::Humans are exposed to mixtures of chemicals, rather than to individual chemicals. From a public health point of view, it is most relevant to answer the question of whether or not the components in a mixture interact in a way that results in an increase in their overall effect compared with the sum of the effects of th...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Groten JP,Feron VJ,Sühnel J

    更新日期:2001-06-01 00:00:00

  • Neurobiology and treatment of Parkinson's disease.

    abstract::Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease and is an important cause of chronic disability. Numerous important advances have been made in our understanding of the aetiopathogenesis, pathology and clinical phenomenology of this disease, and these have underpi...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Schapira AH

    更新日期:2009-01-01 00:00:00

  • The ubiquitin-dependent proteolytic pathway in skeletal muscle: its role in pathological states.

    abstract::It is generally accepted that muscle wasting is caused by an increase in protein breakdown which seems to be associated with an ATP-dependent, non-lysosomal proteolytic system based on conjugation of proteins to the small polypeptide ubiquitin. Increases in ubiquitin conjugates and in ubiquitin mRNAs are found in the ...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Argilés JM,López-Soriano FJ

    更新日期:1996-06-01 00:00:00

  • Allosteric modulation of muscarinic acetylcholine receptors.

    abstract::Five subtypes of muscarinic acetylcholine receptors have been identified in mammalian tissues, but the selectivity of ligands that are active at these receptors is low. It is possible, however, that selective compounds may be developed by targeting their allosteric site(s). Important new insights into the mechanism of...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Tucek S,Proska J

    更新日期:1995-06-01 00:00:00

  • Heterogeneity of the endothelial cell and its role in organ preference of tumour metastasis.

    abstract::The vascular endothelium is a remarkably heterogeneous organ. In addition to well-characterized anatomical diversity in situ, specific differences are increasingly being recognized between surface antigens on endothelial cells from different tissues, including absence of the classic endothelial marker factor VIII-rela...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: McCarthy SA,Kuzu I,Gatter KC,Bicknell R

    更新日期:1991-12-01 00:00:00

  • Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin.

    abstract::Degradation of heme requires its conversion to biliverdin (BV) by heme oxygenase, followed by reduction of BV to the free-radical quencher bilirubin (BR) by biliverdin reductase (BVR). It is now recognized that human BVR (hBVR) is a dual-specificity kinase (Ser/Thr and Tyr) upstream activator of the insulin/insulin gr...

    journal_title:Trends in pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Kapitulnik J,Maines MD

    更新日期:2009-03-01 00:00:00