007 (x2)-3-3: 14-3-3 Targeted Compounds as Double Agents.

Abstract:

:14-3-3 Proteins enact a range of cellular functions through protein-protein interactions (PPIs) with client proteins. Kaplan and colleagues recently demonstrated that a semisynthetic compound was able to selectively stabilize or disrupt specific interactions, depending on the binding partner. This finding presents an exciting possibility of designing other 14-3-3 compounds to regulate critical 14-3-3 interactions.

journal_name

Trends Pharmacol Sci

authors

Gannon M,Yacoubian TA

doi

10.1016/j.tips.2020.05.001

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

431-433

issue

7

eissn

0165-6147

issn

1873-3735

pii

S0165-6147(20)30108-5

journal_volume

41

pub_type

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