Abstract:
:Pharmacological studies as well as molecular cloning of 5-HT receptors have revealed a multiplicity of receptor subtypes, not only in mammals but, as discussed in this review by René Hen, also in molluscs and arthropods. Most of these receptors belong to the G protein-coupled receptor family, and their mechanism of action involves modulating levels of second messengers such as cAMP, IP3 and Ca2+. Rather than being specialized in a particular physiological function, a given receptor may be expressed in multiple neurons throughout the brain but always in the same compartment in these neurons. The 5-HT1B receptor, for example, is generally localized presynaptically on neuronal terminals, where it inhibits neurotransmitter release. A widespread distribution of 5-HT receptors might explain how 5-HT can modulate the multiple neuronal circuits that underlie complex behaviours.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Hen Rdoi
10.1016/0165-6147(92)90054-asubject
Has Abstractpub_date
1992-04-01 00:00:00pages
160-5issue
4eissn
0165-6147issn
1873-3735pii
0165-6147(92)90054-Ajournal_volume
13pub_type
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