Abstract:
:Several lines of evidence suggest that adenosine may be an endogenous protective agent in cerebral ischaemia. Adenosine is normally present in the extracellular fluid in most tissues of the body, including the brain, and its level increases dramatically following hypoxia or ischaemia. The rate of adenosine production is enhanced when the energy demand is larger than the rate of energy supply. Adenosine acts on specific receptors that are present in most cells in the body and that produce cellular effects that tend to antagonize a number of pathological events thought to be instrumental for ischaemic nerve cell death. Karl Rudolphi and colleagues review evidence for the neuroprotective potential of adenosine and indicate some targets for drug development.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Rudolphi KA,Schubert P,Parkinson FE,Fredholm BBdoi
10.1016/0165-6147(92)90141-rsubject
Has Abstractpub_date
1992-12-01 00:00:00pages
439-45issue
12eissn
0165-6147issn
1873-3735pii
0165-6147(92)90141-Rjournal_volume
13pub_type
杂志文章,评审abstract::The potent pro-inflammatory cytokines tumour necrosis factor alpha (TNF-alpha) and interleukin 1 (IL-1) are capable of triggering biologically similar effects through activation of the same set of transcription factors. Based on recent findings it is now becoming evident that certain members of the mitogen-activated p...
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