Abstract:
:The fruit fly Drosophila melanogaster has been used for modeling cancer and as an in vivo tool for the validation and/or development of cancer therapeutics. The impetus for the use of Drosophila in cancer research stems from the high conservation of its signaling pathways, lower genetic redundancy, short life cycle, genetic amenability, and ease of maintenance. Several cell signaling pathways in Drosophila have been used for cancer drug development. The efficacy of combination therapy and uptake/bioavailability of drugs have also been studied. Drosophila has been validated using several FDA-approved drugs, suggesting a potential application of this model in drug repurposing. The model is emerging as a powerful tool for high-throughput screening and should significantly reduce the cost and time associated with drug development. In this review we discuss the applications of Drosophila in cancer drug development. The advantages and limitations of the model are discussed.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Yadav AK,Srikrishna S,Gupta SCdoi
10.1016/j.tips.2016.05.010subject
Has Abstractpub_date
2016-09-01 00:00:00pages
789-806issue
9eissn
0165-6147issn
1873-3735pii
S0165-6147(16)30053-0journal_volume
37pub_type
杂志文章,评审abstract::The pursuit for drugs that inhibit cyclin-dependent kinases (CDKs) has been an intense area of research for more than 15 years. The first-generation inhibitors, Flavopiridol and CY-202, are in late-stage clinical trials, but so far have demonstrated only modest activity. Several second-generation inhibitors are now in...
journal_title:Trends in pharmacological sciences
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journal_title:Trends in pharmacological sciences
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更新日期:2010-11-01 00:00:00
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