CDK inhibitors in cancer therapy: what is next?

Abstract:

:The pursuit for drugs that inhibit cyclin-dependent kinases (CDKs) has been an intense area of research for more than 15 years. The first-generation inhibitors, Flavopiridol and CY-202, are in late-stage clinical trials, but so far have demonstrated only modest activity. Several second-generation inhibitors are now in clinical trials. Future approaches to determine clinical benefit need to incorporate both the lessons learned from these early compounds and information recently obtained from the genetic analysis of CDKs in preclinical models. Here we discuss key concepts that should be considered when validating the clinical utility of CDK inhibitors in cancer therapy.

journal_name

Trends Pharmacol Sci

authors

Malumbres M,Pevarello P,Barbacid M,Bischoff JR

doi

10.1016/j.tips.2007.10.012

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

16-21

issue

1

eissn

0165-6147

issn

1873-3735

pii

S0165-6147(07)00275-1

journal_volume

29

pub_type

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