Nicotine addiction: the possible role of functional upregulation.

Abstract:

:Upregulation of binding to nicotinic acetylcholine receptors (nAChRs) is observed in the brains of both smokers and animals chronically exposed to nicotine, although whether this in vivo change is accompanied by an increase in receptor function is unknown. In vitro recordings indicate that alpha4beta2- and alpha7-subtypes of nAChRs, which are the most abundant subtypes in the brain, are functionally upregulated following prolonged exposure to nicotine. The possible consequences of functional upregulation for nicotine addiction are discussed. Moreover, we propose a new paradigm that describes the unusual behavior of these neuronal nAChRs and helps to explain the effects of nicotine in the CNS and the diffuse effects of ACh.

journal_name

Trends Pharmacol Sci

authors

Buisson B,Bertrand D

doi

10.1016/S0165-6147(00)01979-9

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

130-6

issue

3

eissn

0165-6147

issn

1873-3735

pii

S0165-6147(00)01979-9

journal_volume

23

pub_type

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