Abstract：
:This year marks the 90th anniversary of the publication of Hans Horst Meyer's classic paper in which he proposed that the ability of a substance to produce narcosis or anesthesia is governed by its partition coefficient. In this article, Robert Lipnick describes the experiments carried out by Meyer and his colleagues which disproved the earlier theories that potency was determined by the presence of particular functional groups or their metabolites or by water or fat solubility, and which led to the formulation of the lipoid theory of narcosis.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Lipnick RLdoi
10.1016/0165-6147(89)90025-4subject
Has Abstractpub_date
1989-07-01 00:00:00pages
265-9issue
7eissn
0165-6147issn
1873-3735pii
0165-6147(89)90025-4journal_volume
10pub_type
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