Abstract：
:As we have learnt from earlier articles in our series on the pharmacology of excitatory amino acids, neurons and glia express several subtypes of excitatory amino acid receptor, the activation of which increases intracellular free calcium ion concentration. In this sixth article, Mark Mayer and Richard Miller detail the mechanisms and consequences of this activity. Ionotropic excitatory amino acid receptors, most notably those activated by NMDA, allow Ca2+ influx as a result of passive diffusion down its concentration gradient. Metabotropic receptors trigger an increase in polyphosphoinositide metabolism, and release of Ca2+ from intracellular stores. The increase in [Ca2+]i mediated by excitatory amino acids underlies a complex cellular physiology, including the activation of other second messenger systems, and contributes to the initiation of long-term potentiation.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Mayer ML,Miller RJdoi
10.1016/0165-6147(90)90254-6subject
Has Abstractpub_date
1990-06-01 00:00:00pages
254-60issue
6eissn
0165-6147issn
1873-3735pii
0165-6147(90)90254-6journal_volume
11pub_type
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