'Should I stay or should I go?': myosin V function in organelle trafficking.

Abstract:

:Actin- and microtubule-based motors can propel different cargos along filaments. Within cells, they control the distribution of membrane-bound compartments by performing complementary tasks. Organelles make long journeys along microtubules, with class V myosins ensuring their capture and their dispersal in actin-rich regions. Myosin Va is recruited on to diverse organelles, such as melanosomes and secretory vesicles, by a mechanism involving Rab GTPases. The role of myosin Va in the recruitment of secretory vesicles at the plasma membrane reveals that the cortical actin network cannot merely be seen as a physical barrier hindering vesicle access to release sites. In neurons, myosin Va controls the targeting of IP(3) (inositol 1,4,5-trisphosphate)-sensitive Ca(2+) stores to dendritic spines and the transport of mRNAs. These defects probably account for the severe neurological symptoms observed in Griscelli syndrome due to mutations in the MYO5A gene.

journal_name

Biol Cell

journal_title

Biology of the cell

authors

Desnos C,Huet S,Darchen F

doi

10.1042/BC20070021

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

411-23

issue

8

eissn

0248-4900

issn

1768-322X

pii

BC20070021

journal_volume

99

pub_type

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