Abstract:
:Actin- and microtubule-based motors can propel different cargos along filaments. Within cells, they control the distribution of membrane-bound compartments by performing complementary tasks. Organelles make long journeys along microtubules, with class V myosins ensuring their capture and their dispersal in actin-rich regions. Myosin Va is recruited on to diverse organelles, such as melanosomes and secretory vesicles, by a mechanism involving Rab GTPases. The role of myosin Va in the recruitment of secretory vesicles at the plasma membrane reveals that the cortical actin network cannot merely be seen as a physical barrier hindering vesicle access to release sites. In neurons, myosin Va controls the targeting of IP(3) (inositol 1,4,5-trisphosphate)-sensitive Ca(2+) stores to dendritic spines and the transport of mRNAs. These defects probably account for the severe neurological symptoms observed in Griscelli syndrome due to mutations in the MYO5A gene.
journal_name
Biol Celljournal_title
Biology of the cellauthors
Desnos C,Huet S,Darchen Fdoi
10.1042/BC20070021subject
Has Abstractpub_date
2007-08-01 00:00:00pages
411-23issue
8eissn
0248-4900issn
1768-322Xpii
BC20070021journal_volume
99pub_type
杂志文章,评审abstract::Revision of the reference map of the polytene chromosomes of Drosophila subobscura was started by means of the electron microscope. We present a map of regions 70B to 72D of the E chromosome obtained from squashed and thin-sectioned salivary glands. It was observed that the total number of bands in divisions 70B to 72...
journal_title:Biology of the cell
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doi:10.1111/j.1768-322x.1988.tb00750.x
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journal_title:Biology of the cell
pub_type: 传,历史文章,杂志文章
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journal_title:Biology of the cell
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更新日期:2005-01-01 00:00:00
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journal_title:Biology of the cell
pub_type: 杂志文章
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journal_title:Biology of the cell
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更新日期:2012-01-01 00:00:00
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doi:10.1016/0248-4900(93)90143-3
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journal_title:Biology of the cell
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journal_title:Biology of the cell
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更新日期:2002-05-01 00:00:00
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journal_title:Biology of the cell
pub_type: 杂志文章
doi:
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journal_title:Biology of the cell
pub_type: 杂志文章
doi:10.1111/j.1768-322x.1989.tb00867.x
更新日期:1989-01-01 00:00:00
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journal_title:Biology of the cell
pub_type: 杂志文章
doi:
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journal_title:Biology of the cell
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更新日期:2010-12-01 00:00:00
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journal_title:Biology of the cell
pub_type: 杂志文章
doi:10.1016/0248-4900(93)90129-3
更新日期:1993-01-01 00:00:00
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journal_title:Biology of the cell
pub_type: 杂志文章
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更新日期:1999-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1042/BC20090098
更新日期:2010-02-17 00:00:00
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更新日期:2005-11-01 00:00:00
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journal_title:Biology of the cell
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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journal_title:Biology of the cell
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更新日期:2012-08-01 00:00:00
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journal_title:Biology of the cell
pub_type: 杂志文章
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更新日期:2013-05-01 00:00:00
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journal_title:Biology of the cell
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更新日期:2003-01-01 00:00:00
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journal_title:Biology of the cell
pub_type: 杂志文章,评审
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更新日期:1993-01-01 00:00:00
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journal_title:Biology of the cell
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更新日期:1998-07-01 00:00:00
abstract::The distribution of viral RNA molecules in HeLa cells infected with adenovirus type 5 (Ad5) was determined by in situ hybridization at the ultrastructural level at an intermediate stage of nuclear transformation, when viral DNA synthetic activities were maximal but progeny viruses were still sparse. Transcription site...
journal_title:Biology of the cell
pub_type: 杂志文章
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journal_title:Biology of the cell
pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00
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journal_title:Biology of the cell
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doi:
更新日期:1999-11-01 00:00:00