abstract：BACKGROUND:The translocase of the mitochondrial inner membrane (TIM) imports most of the nucleus-encoded proteins that are destined for the matrix, inner membrane (IM) and the intermembrane space (IMS). Trypanosoma brucei, the infectious agent for African trypanosomiasis, possesses a unique TIM complex consisting of se...

journal_title：Biology of the cell

authors： Singha UK,Tripathi A,Smith JT Jr,Quinones L,Saha A,Singha T,Chaudhuri M

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND INFORMATION:There have been several studies to understand the influence of stiffness of the culture substrates for different types of adherent cells. It is generally accepted that cell proliferation, spreading and focal adhesions increase with higher matrix stiffness. However, what remains unclear is whether...

journal_title：Biology of the cell

authors： Cabriales L,Hautefeuille M,Vázquez-Victorio G,Martinez-Pastor D,Carretero-Ortega J,Jiménez-Escobar A,Macias-Silva M

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND INFORMATION:Claudin-1 (CLDN1) is a four-span transmembrane protein localised at cell-cell tight junctions (TJs), playing an important role in epithelial impermeability and tissue homoeostasis under physiological conditions. Moreover, CLDN1 expression is up-regulated in several cancers, and the level of CLDN1...

journal_title：Biology of the cell

authors： Clément CMH,Deffieu MS,Dorobantu CM,Baumert TF,Ayala-Nunez NV,Mély Y,Ronde P,Gaudin R

更新日期：2020-05-01 00:00:00

abstract：:This review highlights new developments in miRNA as diagnostic and surveillance tools in diseases damaging the renal proximal tubule mediated by endothelin in the field of renal carcinoma, proteinuric kidney disease and tubulotoxicity. A new mechanism in the miRNA regulation of proteins leads to the binding of the miR...

journal_title：Biology of the cell

authors： Fries JWU

更新日期：2019-07-01 00:00:00

abstract：:Infection with Mycobacterium ulcerans results in a necrotising skin disease known as a Buruli ulcer, the pathology of which is directly linked to the bacterial production of the toxin mycolactone. Recent studies have identified the protein translocation machinery of the endoplasmic reticulum (ER) membrane as the prima...

journal_title：Biology of the cell

authors： Demangel C,High S

更新日期：2018-11-01 00:00:00

abstract：:Cells sense and respond to the biochemical and physical properties of the extracellular matrix (ECM) through adhesive structures that bridge the cell cytoskeleton and the surrounding environment. Integrin-mediated adhesions interact with specific ECM proteins and sense the rigidity of the substrate to trigger signalli...

journal_title：Biology of the cell

authors： Seetharaman S,Etienne-Manneville S

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND INFORMATION:The costa is a prominent striated fibre that is found in protozoa of the Trichomonadidae family that present an undulating membrane. It is composed primarily of proteins that have not yet been explored. In this study, we used cell fractionation to obtain a highly enriched costa fraction whose str...

journal_title：Biology of the cell

authors： de Andrade Rosa I,Caruso MB,de Oliveira Santos E,Gonzaga L,Zingali RB,de Vasconcelos ATR,de Souza W,Benchimol M

更新日期：2017-06-01 00:00:00

abstract：:Tensins are focal adhesion molecules that were identified and characterised in the late 1980s to early 1990s. They play an essential role in the control of cell adhesion. Tensins can bind the tail of ß integrin via their phospho tyrosine binding domain, they exhibit various protein interaction domains including a Src ...

journal_title：Biology of the cell

authors： Blangy A

更新日期：2017-03-01 00:00:00

abstract：:After gradually moving away from preparation methods prone to artefacts such as plastic embedding and negative staining for cell sections and single particles, the field of cryo electron microscopy (cryo-EM) is now heading off at unprecedented speed towards high-resolution analysis of biological objects of various siz...

journal_title：Biology of the cell

authors： Orlov I,Myasnikov AG,Andronov L,Natchiar SK,Khatter H,Beinsteiner B,Ménétret JF,Hazemann I,Mohideen K,Tazibt K,Tabaroni R,Kratzat H,Djabeur N,Bruxelles T,Raivoniaina F,Pompeo LD,Torchy M,Billas I,Urzhumtsev A,Klahol

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND INFORMATION:In eukaryotic cells, autophagy is considered a lysosomal catabolic process which participates in the degradation of intracellular components in a vacuolar structure termed autolysosome. This pathway plays a significant role in the erythropoiesis process, contributing to the clearance of some orga...

journal_title：Biology of the cell

authors： Fader CM,Salassa BN,Grosso RA,Vergara AN,Colombo MI

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND INFORMATION:Homotypic internalisation of tumour cells has frequently been observed in tumour tissue sections. Events of non-professional phagocytosis, however, may also occur in normal tissue if the number of dying cells exceeds the phagocytic capacity of professional phagocytes such as macrophages and dendr...

journal_title：Biology of the cell

authors： Schwegler M,Wirsing AM,Dollinger AJ,Abendroth B,Putz F,Fietkau R,Distel LV

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND INFORMATION:Cortactin contributes to growth cone morphogenesis by forming with dynamin, ring-shaped complexes that mechanically bundle and stabilise F-actin. However, the regulatory mechanism of cortactin action is poorly understood. RESULTS:Immunofluorescence microscopy revealed that protein kinase C (PKC)...

journal_title：Biology of the cell

authors： Yamada H,Kikuchi T,Masumoto T,Wei FY,Abe T,Takeda T,Nishiki T,Tomizawa K,Watanabe M,Matsui H,Takei K

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND INFORMATION:In a previous study, we demonstrated that human neutrophils can develop membrane tubulovesicular extensions (TVEs) that are 160-250 nm in width and several micrometres long. These extensions, or cytonemes, are capable of establishing long-range contacts with other cells or bacteria. Cytonemes con...

journal_title：Biology of the cell

authors： Galkina SI,Fedorova NV,Serebryakova MV,Arifulin EA,Stadnichuk VI,Gaponova TV,Baratova LA,Sud'ina GF

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND INFORMATION:Epithelial cadherin (E-cadherin) is involved in cell-cell adhesion through its extracellular domain, whereas the intracellular domain interacts with adaptor proteins, i.e. β-catenin, links E-cadherin to the actin cytoskeleton and participates in signal transduction events. E-cadherin protects mam...

journal_title：Biology of the cell

authors： Rosso M,Lapyckyj L,Amiano N,Besso MJ,Sánchez M,Chuluyan E,Vazquez-Levin MH

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND INFORMATION:There are several reports indicating that starved fibroblasts show higher proliferation rates when re-fed with foetal bovine serum. We have evidence demonstrating that this phenomenon is related to secretory proteins which may be beneficial to wound healing. RESULTS:After re-feeding, 16 and 72 h...

journal_title：Biology of the cell

authors： Golpour M,Fattahi S,Niaki HA,Hadipoor A,Abedian Z,Ahangarian GR,Parsian H,Mosapour A,Khorasani HR,Vaziri HR,Bijani A,Mostafazadeh A

更新日期：2014-05-01 00:00:00

abstract：:In 2001, with-no-lysine (WNK) kinases were identified as the genes responsible for the human hereditary hypertensive disease pseudohypoaldosteronism type II (PHAII). It took a further 6 years to clarify that WNK kinases participate in a signaling cascade with oxidative stress-responsive gene 1 (OSR1), Ste20-related pr...

journal_title：Biology of the cell

authors： Uchida S,Sohara E,Rai T,Sasaki S

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND INFORMATION:The mitogen-inducible gene-6 (Mig-6) is a non-kinase scaffolding adaptor protein. It has been shown that Mig-6 may play important roles in regulating stress response, maintaining homeostasis and functioning as a tumour suppressor. In this study, we investigated the role of Mig-6 in cellular senes...

journal_title：Biology of the cell

authors： Xie B,Zhao L,Chen H,Jin B,Mao Z,Yao Z

更新日期：2013-10-01 00:00:00

abstract：:Brain intricacies and the difficulty that scientists encounter in revealing its function with standard approaches such as electrical stimulation of neurons have led to the exploration of new tools that enable the study of neural circuits in a remote and non-invasive way. To this end, optogenetics has initialised a rev...

journal_title：Biology of the cell

authors： Papagiakoumou E

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND INFORMATION:Matrix metalloproteinases (MMPs) are the key enzymes responsible for the remodelling of extracellular matrix. Two of them, namely MMP-2 and MMP-9 (gelatinases A and B, respectively), are expressed in skeletal muscles and are involved in their regeneration after the injury. Although MMPs are prima...

journal_title：Biology of the cell

authors： Zimowska M,Swierczynska M,Ciemerych MA

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND INFORMATION:The rod outer segment (OS) is the specialised organelle where phototransduction takes place. Our previous proteomic and biochemical analyses on purified rod disks showed the functional expression of the respiratory chain complexes I-IV and F1 Fo -ATP synthase in OS disks, as well as active solubl...

journal_title：Biology of the cell

authors： Calzia D,Barabino S,Bianchini P,Garbarino G,Oneto M,Caicci F,Diaspro A,Tacchetti C,Manni L,Candiani S,Ravera S,Morelli A,Enrico Traverso C,Panfoli I

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND INFORMATION:Autofluorescence spectroscopy is a powerful tool for molecular histology and for following metabolic processes in biological samples as it does not require labelling. However, at the microscopic scale, it is mostly limited to visible and near infrared excitation of the samples. Several interestin...

journal_title：Biology of the cell

authors： Jamme F,Kascakova S,Villette S,Allouche F,Pallu S,Rouam V,Réfrégiers M

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND INFORMATION:Meningothelial cells (MECs) are the cellular components of the meninges protecting the brain and as such provide important barrier function for the central nervous system building the interface between neuronal tissue and the cerebrospinal fluid (CSF). MECs were previously shown to be involved in...

journal_title：Biology of the cell

authors： Li J,Fang L,Killer HE,Flammer J,Meyer P,Neutzner A

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND INFORMATION:Human gingival tissues are prone to hyperplasia under inflammatory stimuli. We have identified gingival tissue-specific mesenchymal stem cells (GMSCs) and found their functional change being correlated with drug-induced gingival hyperplasia. However, whether these cells exhibit characteristics of...

journal_title：Biology of the cell

authors： Li N,Liu N,Zhou J,Tang L,Ding B,Duan Y,Jin Y

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND INFORMATION:The Wiskott-Aldrich syndrome protein and scar homolog (WASH) complex is the major Arp2/3 activator at the surface of endosomes. The branched actin network, that the WASH complex induces, contributes to cargo sorting and scission of transport intermediates destined for most endosomal routes. A maj...

journal_title：Biology of the cell

authors： Helfer E,Harbour ME,Henriot V,Lakisic G,Sousa-Blin C,Volceanov L,Seaman MNJ,Gautreau A

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND INFORMATION:The interferon (IFN)-inducible protein TRIM22 (Staf50) is a member of the tripartite motif protein family and has been suggested a role in the regulation of viral replication as well as of protein ubiquitylation. In addition, we have previously shown that TRIM22 is a direct target gene for the tu...

journal_title：Biology of the cell

authors： Petersson J,Ageberg M,Sandén C,Olofsson T,Gullberg U,Drott K

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND INFORMATION:αvβ5 integrin and Mer tyrosine kinase (MerTK) receptors reside at the apical surface of the retinal pigment epithelium (RPE) in the eye to promote the diurnal, synchronised phagocytosis of shed photoreceptor outer segment fragments (POS) that is critical for vision. Phagocytosis assays studying R...

journal_title：Biology of the cell

authors： Nandrot EF,Silva KE,Scelfo C,Finnemann SC

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND INFORMATION:Continued advances in stem cell biology and stem cell transplantation rely on non-invasive biomarkers to characterise cells and stem cell aggregates. The non-invasive quality of such biomarkers is essential because exogenous labels, probes or reporters can unintentionally and dramatically alter s...

journal_title：Biology of the cell

authors： Buschke DG,Squirrell JM,Fong JJ,Eliceiri KW,Ogle BM

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND INFORMATION:The ribonucleases (RNases) constitute a heterogeneous group of enzymes, which exert diverse and specific biological functions. Several RNases have been shown to control gene expression and cell differentiation. RNASET2, a novel member of the Rh/T2/S family of RNases, exerts micro-environmental co...

journal_title：Biology of the cell

authors： Vidalino L,Monti L,Haase A,Moro A,Acquati F,Taramelli R,Macchi P

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND INFORMATION:The identification of a source of stem cells able to regenerate skeletal muscle was the goal of numerous studies with the aim to develop new therapeutic approaches for genetic muscle diseases or muscle injuries. A series of studies have demonstrated that stem cells derived from various tissues ma...

journal_title：Biology of the cell

authors： Dimicoli-Salazar S,Bulle F,Yacia A,Massé JM,Fichelson S,Vigon I

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND INFORMATION:PrAO (primary amine oxidase), also known as SSAO (semicarbazide-sensitive amine oxidase)/VAP-1 (vascular adhesion protein-1), is an enzyme (EC 1.4.3.21) that is highly expressed in blood vessels and participates in many cell processes, including glucose handling or inflammatory leucocyte recruitm...

journal_title：Biology of the cell

authors： Solé M,Unzeta M

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND INFORMATION:The assembly and maintenance of cilia depend on IFT (intraflagellar transport) mediated by molecular motors and their interplay with IFT proteins. Here, we have analysed the involvement of IFT proteins in the ciliogenesis of mammalian photoreceptor cilia. RESULTS:Electron microscopy revealed tha...

journal_title：Biology of the cell

authors： Sedmak T,Wolfrum U

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND INFORMATION:ROS (reactive oxygen species) as well as components of the antioxidant redox systems may act as signals. To link acute environmental change with gene expression, changes in ROS and GSH/GSSG (reduced/oxidized glutathione) level were measured upon acute changes in temperature or oxygen availability...

journal_title：Biology of the cell

authors： Becker D,Brinkmann BF,Zeis B,Paul RJ

更新日期：2011-08-01 00:00:00

abstract：:LDs (lipid droplets) have long been considered as inert particles used by the cells to store fatty acids and sterols as esterified non-toxic lipid species (i.e. triacylglycerols and steryl esters). However, accumulating evidence suggests that LDs behave as a dynamic compartment, which is involved in the regulation of ...

journal_title：Biology of the cell

authors： Hapala I,Marza E,Ferreira T

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND INFORMATION:Carcinoma of the oesophagus is the sixth leading cause of cancer death in the western world and is associated with a 5-year survival of less than 15%. Recent evidence suggests that stromal-epithelial interactions are fundamental in carcinogenesis. The advent of co-culture techniques permits the i...

journal_title：Biology of the cell

authors： Underwood TJ,Derouet MF,White MJ,Noble F,Moutasim KA,Smith E,Drew PA,Thomas GJ,Primrose JN,Blaydes JP

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND INFORMATION:The BOR (branchio-oto-renal) syndrome is a dominant disorder most commonly caused by mutations in the EYA1 (Eyes Absent 1) gene. Symptoms commonly include deafness and renal anomalies. RESULTS:We have used the embryos of the frog Xenopus laevis as an animal model for early ear development to exa...

journal_title：Biology of the cell

authors： Li Y,Manaligod JM,Weeks DL

更新日期：2010-02-17 00:00:00

abstract：:ESCRTs (endosomal sorting complexes required for transport) were first discovered in yeast and are known to be required in the biogenesis of the MVB (multivesicular body). Most ESCRT research has been carried out in vitro using models such as yeast and mammalian cells in culture. The role of the ESCRTs genes in endoso...

journal_title：Biology of the cell

authors： Michelet X,Djeddi A,Legouis R

更新日期：2010-01-13 00:00:00

abstract：BACKGROUND INFORMATION:CLEM (correlative live cell and electron microscopy) seeks to bridge the data acquired with different imaging strategies, typically between light microscopy and electron microscopy. It has been successfully applied in cell cultures, although its use in multicellular systems is hampered by difficu...

journal_title：Biology of the cell

authors： Kolotuev I,Schwab Y,Labouesse M

更新日期：2009-12-04 00:00:00

abstract：BACKGROUND:Integrins are transmembrane alphabeta heterodimer receptors that function as structural and functional bridges between the cytoskeleton and ECM (extracellular matrix) molecules. The RGD (arginine-glycine-aspartate tripeptide motif)-dependent integrin alpha8beta1 has been shown to be involved in various cell ...

journal_title：Biology of the cell

authors： Benoit YD,Lussier C,Ducharme PA,Sivret S,Schnapp LM,Basora N,Beaulieu JF

更新日期：2009-09-14 00:00:00

abstract：BACKGROUND INFORMATION:Caspase-dependent and -independent death mechanisms are involved in apoptosis in a variety of human carcinoma cells treated with antineoplastic compounds. Our laboratory has reported that p53 is a key contributor of mitochondrial apoptosis in cervical carcinoma cells after staurosporine exposure....

journal_title：Biology of the cell

authors： Nicolier M,Decrion-Barthod AZ,Launay S,Prétet JL,Mougin C

更新日期：2009-06-04 00:00:00

abstract：BACKGROUND INFORMATION:The endometrial epithelial cell membrane is a key interface in female reproductive biology. Steroid hormones play a predominant role in cyclic changes which occur at this interface during the female menstrual cycle. Specific changes in the morphology of the endometrial epithelial cell surface bec...

journal_title：Biology of the cell

authors： Francis LW,Lewis PD,Gonzalez D,Ryder TA,Webb G,Joels LA,White JO,Wright CJ,Conlan RS

更新日期：2009-06-04 00:00:00