Fission yeast cytoskeletons and cell polarity factors: connecting at the cortex.

Abstract:

:Cell polarity is a fundamental property of cells from unicellular to multicellular organisms. Most of the time, it is essential so that the cells can achieve their function. The fission yeast Schizosaccharomyces pombe is a powerful genetic model organism for studying the molecular mechanisms of the cell polarity process. Indeed, S. pombe cells are rod-shaped and cell growth is restricted at the poles. The accurate localization of the cell growth machinery at the cell cortex, which involves the actin cytoskeleton, depends on cell polarity pathways that are temporally and spatially regulated. The importance of interphase microtubules and cell polarity factors acting at the cortex of cell ends in this process has been shown. Here, we review recent advances in knowledge of molecular pathways leading to the establishment of a cellular axis in fission yeast. We also describe the role of cortical proteins and mitotic cytoskeletal rearrangements that control the symmetry of cell division.

journal_name

Biol Cell

journal_title

Biology of the cell

authors

La Carbona S,Le Goff C,Le Goff X

doi

10.1042/BC20060048

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

619-31

issue

11

eissn

0248-4900

issn

1768-322X

pii

BC20060048

journal_volume

98

pub_type

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