Flow DNA analysis in human lung cancer: potentiality and limitations due to sampling methods.

Abstract:

:Flow DNA analysis was performed on samples from 71 surgically removed lung cancers and from 145 patients undergoing bronchoscopy. Abnormal DNA stem lines, characterized by their DNA index (DI), were frequently observed in operated lung carcinomas (87%). Two or three abnormal DNA stem lines were discovered simultaneously in 10% of the samples. The mean DI of all abnormal tumor stem lines was lowest for rare tumor cell types and highest for adenocarcinomas. Intermediate mean DI values were found for epidermoid and small cell carcinomas, which were among the most proliferative tumors. The high rate of false negative results suggests poor diagnostic reliability of flow DNA analysis on bronchoscopic samples. However, the method appears to provide a promising objective tool capable of evaluating tumor behavior and prognosis.

journal_name

Biol Cell

journal_title

Biology of the cell

authors

Chassevent A,Berruchon J,Bertrand G,Chretien MF,Tuchais C,George P,Larra F,Rebel A,Oury M

doi

10.1111/j.1768-322x.1986.tb00494.x

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

121-6

issue

2

eissn

0248-4900

issn

1768-322X

journal_volume

58

pub_type

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